OMIX006614

1Summary

Title	Dietary Cholesterol Promotes Cognitive Impairment
Description	Dietary cholesterol is often found in high-fat diet (HFD) and may be harmful to cognitive function. The gut microbiome represents an environmental factor influenced by diet, which regulates cognitive function via the gut-brain axis. This study investigated the role of dietary cholesterol in HFD-induced cognitive impairment, as well as the involvement of the gut microbiota and its metabolites in this process.
Organism	Mus musculus
Data Type	Metabolome Data by Mass Spectrometry (MS)
Data Accessibility	Open-access
BioProject	PRJCA026860
Release Date	2025-09-30
Submitter	Yan Liu (ly505469330@163.com)
Organization	Zhejiang University
Submission Date	2024-06-07

2Files & Download

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File ID	File Title	Number/Samples	File Type	File Size	File Suffix	Download
OMIX006614-01	NEG_HFD1.raw	1	Metabolome Data by Mass Spectrometry (MS)	97.14 MB	raw	FTP HTTPs
OMIX006614-02	NEG_HFD2.raw	1	Metabolome Data by Mass Spectrometry (MS)	96.99 MB	raw	FTP HTTPs
OMIX006614-03	NEG_HFD3.raw	1	Metabolome Data by Mass Spectrometry (MS)	99.54 MB	raw	FTP HTTPs
OMIX006614-04	NEG_HFD4.raw	1	Metabolome Data by Mass Spectrometry (MS)	99.38 MB	raw	FTP HTTPs
OMIX006614-05	NEG_HFD5.raw	1	Metabolome Data by Mass Spectrometry (MS)	99.43 MB	raw	FTP HTTPs
OMIX006614-06	NEG_HFHCD1.raw	1	Metabolome Data by Mass Spectrometry (MS)	96.13 MB	raw	FTP HTTPs
OMIX006614-07	NEG_HFHCD2.raw	1	Metabolome Data by Mass Spectrometry (MS)	97.08 MB	raw	FTP HTTPs
OMIX006614-08	NEG_HFHCD3.raw	1	Metabolome Data by Mass Spectrometry (MS)	96.43 MB	raw	FTP HTTPs
OMIX006614-09	NEG_HFHCD4.raw	1	Metabolome Data by Mass Spectrometry (MS)	97.45 MB	raw	FTP HTTPs
OMIX006614-10	NEG_HFHCD5.raw	1	Metabolome Data by Mass Spectrometry (MS)	96.87 MB	raw	FTP HTTPs
OMIX006614-11	NEG_QC01.raw	1	Metabolome Data by Mass Spectrometry (MS)	98.23 MB	raw	FTP HTTPs
OMIX006614-12	NEG_QC02.raw	1	Metabolome Data by Mass Spectrometry (MS)	98.31 MB	raw	FTP HTTPs
OMIX006614-13	NEG_QC03.raw	1	Metabolome Data by Mass Spectrometry (MS)	99.27 MB	raw	FTP HTTPs
OMIX006614-14	POS_HFD1.raw	1	Metabolome Data by Mass Spectrometry (MS)	91.49 MB	raw	FTP HTTPs
OMIX006614-15	POS_HFD2.raw	1	Metabolome Data by Mass Spectrometry (MS)	92.5 MB	raw	FTP HTTPs
OMIX006614-16	POS_HFD3.raw	1	Metabolome Data by Mass Spectrometry (MS)	92.18 MB	raw	FTP HTTPs
OMIX006614-17	POS_HFD4.raw	1	Metabolome Data by Mass Spectrometry (MS)	92.27 MB	raw	FTP HTTPs
OMIX006614-18	POS_HFD5.raw	1	Metabolome Data by Mass Spectrometry (MS)	92.08 MB	raw	FTP HTTPs
OMIX006614-19	POS_HFHCD1.raw	1	Metabolome Data by Mass Spectrometry (MS)	91.09 MB	raw	FTP HTTPs
OMIX006614-20	POS_HFHCD2.raw	1	Metabolome Data by Mass Spectrometry (MS)	90.69 MB	raw	FTP HTTPs
OMIX006614-21	POS_HFHCD3.raw	1	Metabolome Data by Mass Spectrometry (MS)	91.53 MB	raw	FTP HTTPs
OMIX006614-22	POS_HFHCD4.raw	1	Metabolome Data by Mass Spectrometry (MS)	90.77 MB	raw	FTP HTTPs
OMIX006614-23	POS_HFHCD5.raw	1	Metabolome Data by Mass Spectrometry (MS)	91.47 MB	raw	FTP HTTPs
OMIX006614-24	POS_QC01.raw	1	Metabolome Data by Mass Spectrometry (MS)	91.08 MB	raw	FTP HTTPs
OMIX006614-25	POS_QC02.raw	1	Metabolome Data by Mass Spectrometry (MS)	91.91 MB	raw	FTP HTTPs
OMIX006614-26	POS_QC03.raw	1	Metabolome Data by Mass Spectrometry (MS)	92.54 MB	raw	FTP HTTPs

3Relevant Publications

Paper Title	Journal Name	Publish Time	Accession	Citing Type
Dietary cholesterol impairs cognition via gut microbiota-derived deoxycholic acid in obese mice	Gut Microbes	2025-07	OMIX006614	Deposit

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