Discovery of novel non-small-cell lung cancer genes in an alternative polyadenylation transcriptome-wide association study
| Title | Discovery of novel non-small-cell lung cancer genes in an alternative polyadenylation transcriptome-wide association study |
|---|---|
| Description | Alternative polyadenylation (APA) plays an essential role in cancer carcinogenesis and prognosis. However, the molecular characteristics of APA related to non-small cell lung cancer (NSCLC) susceptibility are understudied in East Asian populations. In this study, we constructed an atlas of APA-regulated 3'untranslated regions (3'UTR) profiles using RNA and matched DNA sequencing data from 417 Chinese NSCLC patients. We performed a 3'UTR APA transcriptome-wide association study (3'aTWAS) integrating genome-wide association studies in East Asians (7,035 cases and 185,413 controls) and identified three novel NSCLC-associated genes. In summary, we provided a road map for investigating the effects of genetic regulation in East Asian populations and demonstrated the substantial role of APA in NSCLC carcinogenesis and prognosis. |
| Organism | Homo sapiens |
| Data Type | Expression Profiling by NGS |
| Data Accessibility | Controlled-access |
| BioProject | PRJCA026958 |
| Release Date | 2024-08-22 |
| Submitter | xifeng Wu (xifengw@zju.edu.cn) |
| Organization | Zhejiang University School |
| Submission Date | 2024-06-12 |
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| File ID | File Title | Number/Samples | File Type | File Size | File Suffix | Download Times | Download |
|---|---|---|---|---|---|---|---|
| OMIX006665-01 | Discovery of novel non-small-cell lung cancer genes in an alternative polyadenylation transcriptome-wide association study | 747 | Expression Profiling by NGS | 3.4 MB | xlsx | 0 | Controlled |