CCL19-producing fibroblasts promote tertiary lymphoid structures formation augmenting anti-tumor IgG response in colorectal cancer liver metastasis
| Title | CCL19-producing fibroblasts promote tertiary lymphoid structures formation augmenting anti-tumor IgG response in colorectal cancer liver metastasis |
|---|---|
| Description | We provide a comprehensive comparative analysis of the immune ecosystems of CRLM with or without TLSs by spatial enhanced resolution omics-sequencing (Stereo-seq) (from 10 patients) and single cell RNA-sequencing (scRNA-seq) (from 14 patients). We disclose an important link between IgG+ PCs and TLSs, underlining the crucial role of IgG responses in anti-tumor immunity. We also find that fibroblast-derived CCL19 regulate B cell recruitment and TLSs formation, which can be a promising target to promote TLSs neogenesis and suppress CRLM growth. |
| Organism | Homo sapiens |
| Data Type | Other Type of Genomic Data |
| Data Accessibility | Controlled-access |
| BioProject | PRJCA026987 |
| Release Date | 2024-08-12 |
| Submitter | Ming Kuang (kuangm@mail.sysu.edu.cn) |
| Organization | The First Affiliated Hospital, Sun Yat-sen University |
| Submission Date | 2024-06-12 |
The data cannot be downloaded as it has not yet been registered in the Human Genetic Resource Management Platform of MOST.
| File ID | File Title | Number/Samples | File Type | File Size | File Suffix | Download Times | Download |
|---|---|---|---|---|---|---|---|
| OMIX006673-01 | 3484B | 1 | Other Type of Genomic Data | 956.58 MB | gem.gz | 0 | Unavailable |
| OMIX006673-02 | 3346B | 1 | Other Type of Genomic Data | 645.71 MB | gem.gz | 0 | Unavailable |
| OMIX006673-03 | 2905B | 1 | Other Type of Genomic Data | 1.02 GB | gem.gz | 0 | Unavailable |
| OMIX006673-04 | 2840B | 1 | Other Type of Genomic Data | 1 GB | gem.gz | 0 | Unavailable |
| OMIX006673-05 | 3492B | 1 | Other Type of Genomic Data | 849.26 MB | gem.gz | 0 | Unavailable |
| OMIX006673-06 | 3373B | 1 | Other Type of Genomic Data | 684.67 MB | gem.gz | 0 | Unavailable |
| OMIX006673-07 | 3407B | 1 | Other Type of Genomic Data | 880.48 MB | gem.gz | 0 | Unavailable |
| OMIX006673-08 | 2938B | 1 | Other Type of Genomic Data | 1.1 GB | gem.gz | 0 | Unavailable |
| OMIX006673-09 | 2801B | 1 | Other Type of Genomic Data | 847.81 MB | gem.gz | 0 | Unavailable |
| OMIX006673-10 | 3471B | 1 | Other Type of Genomic Data | 911.25 MB | gem.gz | 0 | Unavailable |