De novo generation of macrophage from placenta-derived hemogenic endothelium
| Title | De novo generation of macrophage from placenta-derived hemogenic endothelium |
|---|---|
| Description | We profile the transcriptional landscape of mouse fetal placenta and identify four distinct types of haematopoietic stem/progenitor cells (HSPCs) during mid-gestation using single-cell RNA sequencing. We experimentally validate and uncover that a subpopulation of placental endothelial cells exhibits hemogenic endothelial (HE) potential and shares transcriptional features with HE cells in the aorta-gonad-mesonephros (AGM) region. |
| Organism | Mus musculus |
| Data Type | Other Type of Genomic Data |
| Data Accessibility | Open-access |
| BioProject | PRJCA026998 |
| Release Date | 2024-08-31 |
| Submitter | HCD liulab (hcdliulab@126.com) |
| Organization | Institute of Zoology, Chinese Academy of Sciences |
| Submission Date | 2024-06-22 |
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| File ID | File Title | Number/Samples | File Type | File Size | File Suffix | Download Times | Download |
|---|---|---|---|---|---|---|---|
| OMIX006720-01 | 10x_Raw_gene_counts_matrix | 1 | Other Type of Genomic Data | 1.86 GB | txt | 0 | |
| OMIX006720-02 | 10x_Celltype | 2 | Other Type of Genomic Data | 869.17 KB | txt | 0 | |
| OMIX006720-03 | Smart-seq2-GFP_Raw_gene_counts_matrix | 3 | Other Type of Genomic Data | 49.57 MB | txt | 0 | |
| OMIX006720-04 | placental_cells_barcodes | 4 | Other Type of Genomic Data | 68.85 KB | tsv | 0 | |
| OMIX006720-05 | placental_cells_genes | 5 | Other Type of Genomic Data | 217.25 KB | tsv | 0 | |
| OMIX006720-06 | placental_cells_matrix | 6 | Other Type of Genomic Data | 205.02 MB | matrix.mtx | 0 |