OMIX006736

1Summary
Title A genome-wide expression profiling data of 81 rectal cancer patients with neoadjuvant chemoradiotherapy
Description To explore whether gene expression profiles of primary rectal carcinomas could offer a specific gene signature that determine response to preoperative chemoradiotherapy, we conducted a study with eighty-one individuals with locally advanced rectal carcinomas to establish a molecular signature for response classification based on genome-wide mRNA expression analysis. Class-comparison statistics between good response patients (Tumor Regression Grade 1 and 2) and poor response patients (Tumor Regression Grade 4 and 5) were used to correlate the expression results with tumor regression grade after preoperative chemoradiotherapy.
Organism Homo sapiens
Data Type Expression Profiling by Array
Data Accessibility Controlled-access
BioProject PRJCA027384
Release Date 2024-06-26
Submitter ningxin Ren (renningxin01@163.com)
Organization National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital
Submission Date 2024-06-25
2Files & Download

The data cannot be downloaded as it has not yet been registered in the Human Genetic Resource Management Platform of MOST.

File ID File Title Number/Samples File Type File Size File Suffix Download
OMIX006736-01 A genome-wide expression profiling data of 81 rectal cancer patients with neoadjuvant chemoradiotherapy 97 Expression Profiling by Array 330.2 MB zip Unavailable
3Relevant Publications
Paper Title Journal Name Publish Time Accession Citing Type
ZNF37A downregulation promotes TNFRSF6B expression and leads to therapeutic resistance to concurrent chemoradiotherapy in rectal cancer patients Translational Oncology 2024-11 OMIX006736 Deposit
MDM1 overexpression promotes p53 expression and cell apoptosis to enhance therapeutic sensitivity to chemoradiotherapy in patients with colorectal cancer Cancer Biology & Medicine 2025-04 OMIX006736 Deposit
Kinesin Family Member 26A Disrupts DNA-Dependent Protein Kinase Complex Formation to Enhance Chemoradiotherapy Sensitivity in Colorectal Cancer International Journal of Biological Sciences 2026-03 OMIX006736 Deposit

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