Identification and Function of Key Metabolites in Organogenesis
| Title | Identification and Function of Key Metabolites in Organogenesis |
|---|---|
| Description | This project aims to delve deeper into this phenomenon by examining embryonic stem cells, induced pluripotent stem (iPS) cells, and cells or organoids at various stages of differentiation towards neural and hepatocyte lineages. Our objectives are to identify key metabolic intermediates and pathways that govern the maintenance of pluripotency and differentiation into neural or hepatocyte cells, elucidate the specific molecular mechanisms underlying their regulation, and investigate the role of mitochondria-related proteins in the maintenance of stem cell pluripotency and their differentiation into neural tube and hepatocyte cells. To achieve these goals, we will construct knockout mouse models targeting key metabolic enzymes or mitochondria-related proteins, as well as mouse models derived from haploid stem cells, to validate the functional roles of these key metabolites, pathways, and mitochondria-related proteins in vivo. |
| Organism | Homo sapiens |
| Data Type | Proteomic Data by Mass Spectrometry (MS) |
| Data Accessibility | Open-access |
| BioProject | PRJCA027535 |
| Release Date | 2024-07-01 |
| Submitter | shengqi shen (ssq@mail.ustc.edu.cn) |
| Organization | GDPH |
| Submission Date | 2024-07-01 |
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| File ID | File Title | Number/Samples | File Type | File Size | File Suffix | Download Times | Download |
|---|---|---|---|---|---|---|---|
| OMIX006784-01 | SND1 binding proteins | 4 | Proteomic Data by Mass Spectrometry (MS) | 2.31 GB | zip | 0 | |
| OMIX006784-02 | CaMKK2 binding proteins | 2 | Proteomic Data by Mass Spectrometry (MS) | 804.56 MB | zip | 0 | |
| OMIX006784-03 | Metformin treated proteins | 3 | Proteomic Data by Mass Spectrometry (MS) | 1.71 GB | zip | 0 |