Inactivation of Malic Enzyme 1 in Endothelial Cells Alleviates Pulmonary Hypertension
| Title | Inactivation of Malic Enzyme 1 in Endothelial Cells Alleviates Pulmonary Hypertension |
|---|---|
| Description | We found that Malic Enzyme 1 protein level and enzymatic activity were highly elevated in lung tissues of patients and mice with Pulmonary Hypertension, primarily in vascular endothelial cells. Global knockout of Malic Enzyme 1 protected mice from developing hypoxia or induced Pulmonary Hypertension. Endothelial-specific Malic Enzyme deletion similarly attenuated pulmonary vascular remodeling and Pulmonary Hypertension envelopment in mice, suggesting a critical role of endothelial Malic Enzyme in Pulmonary Hypertension. |
| Organism | Homo sapiens |
| Data Type | Metabolome Data by Mass Spectrometry (MS) |
| Data Accessibility | Open-access |
| BioProject | PRJCA028123 |
| Release Date | 2024-07-17 |
| Submitter | wei li (942013819@qq.com) |
| Organization | Institute of Basic Medical Sciences Chinese Academy of Medical Sciences, School of Basic Medicine Peking Union Medical College |
| Submission Date | 2024-07-16 |
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| File ID | File Title | Number/Samples | File Type | File Size | File Suffix | Download Times | Download |
|---|---|---|---|---|---|---|---|
| OMIX006889-01 | Inactivation of Malic Enzyme 1 in Endothelial Cells Alleviates Pulmonary Hypertension | 1 | Metabolome Data by Mass Spectrometry (MS) | 77.6 KB | xlsx | 0 |