| Title | Metabolomics analysis of outer membrane vesicles derived from Parabacteroides goldsteinii |
|---|---|
| Description | Despite gut microbiota-derived extracellular vesicles (EVs) serving as pivotal mediators in bacteria-host cell interactions, their potential role in modulating skin inflammation remains poorly understood. Here, we developed strategies for mass production of Parabacteroides goldsteinii JCM 1344 derived outer membrane vesicles (OMVs), commonly known as EVs. In order to identify the components driving the Immunomodulation of Pg OMVs, we performed multi-omics analysis of Pg OMVs. OMVs mediated delivery of metabolites to host cells is an important mechanism of host-pathogen communication. We performed metabolomics analysis and found that Pg OMVs acquired the majority of metabolites from the parental bacteria. |
| Organism | Bacteria |
| Data Type | Metabolome Data by Mass Spectrometry (MS) |
| Data Accessibility | Open-access |
| BioProject | PRJCA031145 |
| Release Date | 2025-04-29 |
| Submitter | Fang Cheng (chengf9@mail.sysu.edu.cn) |
| Organization | Sun Yat-sen University |
| Submission Date | 2024-10-16 |
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| File ID | File Title | Number/Samples | File Type | File Size | File Suffix | Download |
|---|---|---|---|---|---|---|
| OMIX007647-01 | positive ion modes-Pg-OMVs | 3 | Metabolome Data by Mass Spectrometry (MS) | 102.6 MB | rar | |
| OMIX007647-02 | negative ion modes-Pg-OMVs | 3 | Metabolome Data by Mass Spectrometry (MS) | 93.1 MB | rar |
| Paper Title | Journal Name | Publish Time | Accession | Citing Type |
|---|---|---|---|---|
| Journal of Controlled Release | Journal of Controlled Release | 2025-01 | OMIX007647 | Deposit |