OMIX008014

1Summary
Title Single-cell eQTL mapping reveals novel cell type-specific genes associated with the risk of gastric cancer
Description Nearly all expression quantitative trait loci (eQTL) analyses have been conducted in heterogeneous gastric tissues rather than specific cell types. Here, we used pooled multiplexing strategy to profile approximate 0.4 million gastric cells collected from 203 donors and performed eQTL analyses in 19 gastric cell types. We identified 8,498 independent eQTLs in different cell types, and observed a considerable fraction (81%, 6,909/8,498) cell type-specific effects. Integration of gastric cell type eQTLs with genome-wide association studies for gastric cancer (GC) revealed four newly reported co-localization signals in different cell types. Moreover, genetically predicted cell type-specific gene expression identified 20 genes associated with GC risk, such as up-regulation of MUC1 only in parietal cells was associated with a decreased GC risk.
Organism Homo sapiens
Data Type Expression Profiling
Data Accessibility Controlled-access
BioProject PRJCA031019
Release Date 2025-01-02
Submitter Guangfu Jin (guangfujin@njmu.edu.cn)
Organization Nanjing Medical University
Submission Date 2024-11-26
Request for this Data
2Files & Download

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File ID File Title Number/Samples File Type File Size File Suffix Download
OMIX008014-01 Results of co-localization signals in different gastric cell types 1 Expression Profiling 11.52 MB txt.gz Controlled
OMIX008014-02 Results of Plasma composition GWAS 1 Expression Profiling 44.22 MB txt.gz Controlled
OMIX008014-03 Results of CD8 composition GWAS 1 Expression Profiling 43.44 MB txt.gz Controlled
OMIX008014-04 Results of Tip composition GWAS 1 Expression Profiling 43.59 MB txt.gz Controlled
OMIX008014-05 Results of CD4 composition GWAS 1 Expression Profiling 43.25 MB txt.gz Controlled
OMIX008014-06 Results of Stalk composition GWAS 1 Expression Profiling 44.14 MB txt.gz Controlled
OMIX008014-07 Results of Mast composition GWAS 1 Expression Profiling 43.87 MB txt.gz Controlled
OMIX008014-08 Results of Pit composition GWAS 1 Expression Profiling 43.48 MB txt.gz Controlled
OMIX008014-09 Results of Parietal composition GWAS 1 Expression Profiling 44.4 MB txt.gz Controlled
OMIX008014-10 Results of Enterocytes composition GWAS 1 Expression Profiling 44.41 MB txt.gz Controlled
OMIX008014-11 Results of Endocrine composition GWAS 1 Expression Profiling 44.52 MB txt.gz Controlled
OMIX008014-12 Results of Neck composition GWAS 1 Expression Profiling 43.72 MB txt.gz Controlled
OMIX008014-13 Results of M2 composition GWAS 1 Expression Profiling 43.03 MB txt.gz Controlled
OMIX008014-14 Results of Myo composition GWAS 1 Expression Profiling 43.64 MB txt.gz Controlled
OMIX008014-15 Results of DCs composition GWAS 1 Expression Profiling 43.66 MB txt.gz Controlled
OMIX008014-16 Results of M1 composition GWAS 1 Expression Profiling 43.03 MB txt.gz Controlled
OMIX008014-17 Results of Chief composition GWAS 1 Expression Profiling 43.99 MB txt.gz Controlled
OMIX008014-18 Results of Inflammatory composition GWAS 1 Expression Profiling 44.86 MB txt.gz Controlled
OMIX008014-19 Results of Naive composition GWAS 1 Expression Profiling 43.77 MB txt.gz Controlled
OMIX008014-20 Results of Arterial composition GWAS 1 Expression Profiling 44.12 MB txt.gz Controlled
OMIX008014-21 eQTL results of Bulk101 1 Expression Profiling 843.08 MB allpairs.txt.gz Controlled
OMIX008014-22 eQTL results of M1 1 Expression Profiling 328.89 MB allpairs.txt.gz Controlled
OMIX008014-23 eQTL results of Stalk 1 Expression Profiling 505.09 MB allpairs.txt.gz Controlled
OMIX008014-24 eQTL results of Enterocytes 1 Expression Profiling 405.32 MB allpairs.txt.gz Controlled
OMIX008014-25 eQTL results of Naive 1 Expression Profiling 364.32 MB allpairs.txt.gz Controlled
OMIX008014-26 eQTL results of Myo 1 Expression Profiling 409.98 MB allpairs.txt.gz Controlled
OMIX008014-27 eQTL results of Neck 1 Expression Profiling 518.27 MB allpairs.txt.gz Controlled
OMIX008014-28 eQTL results of Plasma 1 Expression Profiling 377.18 MB allpairs.txt.gz Controlled
OMIX008014-29 eQTL results of Chief 1 Expression Profiling 479.27 MB allpairs.txt.gz Controlled
OMIX008014-30 eQTL results of CD8 1 Expression Profiling 404.04 MB allpairs.txt.gz Controlled
OMIX008014-31 eQTL results of Tip 1 Expression Profiling 465.96 MB allpairs.txt.gz Controlled
OMIX008014-32 eQTL results of Parietal 1 Expression Profiling 436.19 MB allpairs.txt.gz Controlled
OMIX008014-33 eQTL results of DCs 1 Expression Profiling 430.51 MB allpairs.txt.gz Controlled
OMIX008014-34 eQTL results of Pit 1 Expression Profiling 520.01 MB allpairs.txt.gz Controlled
OMIX008014-35 eQTL results of CD4 1 Expression Profiling 360.53 MB allpairs.txt.gz Controlled
OMIX008014-36 eQTL results of M2 1 Expression Profiling 357.24 MB allpairs.txt.gz Controlled
OMIX008014-37 eQTL results of Inflammatory 1 Expression Profiling 476.59 MB allpairs.txt.gz Controlled
OMIX008014-38 eQTL results of Endocrine 1 Expression Profiling 555.01 MB allpairs.txt.gz Controlled
OMIX008014-39 eQTL results of Arterial 1 Expression Profiling 356.09 MB allpairs.txt.gz Controlled
OMIX008014-40 eQTL results of Mast 1 Expression Profiling 374.17 MB allpairs.txt.gz Controlled
OMIX008014-41 TWAS results of GC across gastric cell types 1 Expression Profiling 281.7 KB txt.gz Controlled
OMIX008014-42 Gene expression matrix 1 Expression Profiling 600.65 MB tsv.gz Controlled
OMIX008014-43 meta data for matrix 1 Expression Profiling 30.17 MB csv Controlled
3Relevant Publications
Paper Title Journal Name Publish Time Accession Citing Type
Single-cell eQTL mapping reveals cell-type-specific genes associated with the risk of gastric cancer Cell Genomics 2025-03 OMIX008014 Deposit

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