| Title | Identification of glutamine as a potential therapeutic target in dry eye disease |
|---|---|
| Description | Herein, we proposed a novel approach to modulate the inflammation through metabolic remodeling, thus promoting dry eye recovery. We demonstrated that co-treatment with MSCs and thymosin beta-4 (Tβ4) yielded the best therapeutic outcome against dry eye. Inhibition of glutamine reversed the anti-inflammatory, anti-apoptotic, and homeostasis-preserving effects observed with combined therapy, highlighting the critical role of glutamine in dry eye therapy. Clinical cases and rodent model showed elevated expression of glutaminase (GLS1), an upstream enzyme in glutamine metabolism, following dry eye injury. Mechanistic studies indicated that overexpression and inhibition of GLS1 counteracted and enhanced, respectively, the anti-inflammatory effects of combined therapy, underscoring GLS1's pivotal role in regulating glutamine metabolism. |
| Organism | Rattus norvegicus |
| Data Type | Expression Profiling |
| Data Accessibility | Open-access |
| BioProject | PRJCA033622 |
| Release Date | 2025-02-01 |
| Submitter | Min Zhang (mzhangcool@yeah.net) |
| Organization | the First Medical Center of PLA General Hospital |
| Submission Date | 2024-12-13 |
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| File ID | File Title | Number/Samples | File Type | File Size | File Suffix | Download |
|---|---|---|---|---|---|---|
| OMIX008264-01 | DED 2 | 1 | Expression Profiling | 14.45 MB | tar.gz | |
| OMIX008264-02 | Control 1 | 1 | Expression Profiling | 15.12 MB | tar.gz | |
| OMIX008264-03 | GLS treatment 1 | 1 | Expression Profiling | 18.53 MB | tar.gz | |
| OMIX008264-04 | GLS treatment 2 | 1 | Expression Profiling | 10.52 MB | tar.gz | |
| OMIX008264-05 | GLS treatment 3 | 1 | Expression Profiling | 15.29 MB | tar.gz | |
| OMIX008264-06 | Control 3 | 1 | Expression Profiling | 21.62 MB | tar.gz | |
| OMIX008264-07 | Control 2 | 1 | Expression Profiling | 22.37 MB | tar.gz | |
| OMIX008264-08 | DED 1 | 1 | Expression Profiling | 18.75 MB | tar.gz | |
| OMIX008264-09 | DED 3 | 1 | Expression Profiling | 19.8 MB | tar.gz |
| Paper Title | Journal Name | Publish Time | Accession | Citing Type |
|---|---|---|---|---|
| Identification of glutamine as a potential therapeutic target in dry eye disease | Signal Transduction and Targeted Therapy | 2025-01 | OMIX008264 | Deposit |