| Title |
Identification of metabolites associated with capecitabine-induced hand-foot syndrome using untargeted metabolomics in patients with cancer |
| Description |
Hand-foot syndrome (HFS) is defined as a major adverse reaction to capecitabine; however, the underlying mechanisms remain unclear. In total, 85 patients who were taking oral capecitabine were included in the present study, and these patients were divided into HFS-positive and HFS-negative groups. Serum samples were collected from patients, and an untargeted metabolomics analysis was conducted using ultra-high performance liquid chromatography-mass spectrometry/mass spectrometry (UHPLC-MS/MS). The present study aimed to investigate the presence of metabolites in the serum of patients that developed HFS in response to capecitabine treatment. A total of 193 differential metabolites were identified, with 134 upregulated and 59 downregulated. Bioinformatics analysis revealed four novel metabolites that may be associated with HFS. |
| Organism |
Homo sapiens |
| Data Type |
Metabolome Data by Mass Spectrometry (MS) |
| Data Accessibility |
Open-access |
| BioProject |
PRJCA037033 |
| Release Date |
2025-03-12 |
| Submitter |
Yuru Bai (995816758@qq.com) |
| Organization |
Nanjing Jiangning Hospital of Traditional Chinese Medicine |
| Submission Date |
2025-03-07 |