| Title | Organ-Specific Toxicity of SN-38 in Mice: A Comprehensive Study Using Metabolomics. |
|---|---|
| Description | SN-38 (7-ethyl-10-hydroxycamptothecin), the active metabolite of irinotecan, is a crucial anticancer agent frequently studied in drug delivery systems. To explore SN-38s toxic mechanisms and provide insights for clinical applications of SN-38 delivery systems, we performed untargeted metabolomics to assess metabolic changes in the lungs, heart, stomach, blood, spleen, intestine, liver, and kidneys of SN-38-exposed male mice. Mice were divided into two groups: SN-38 (20 mg/kg/day intraperitoneal) and control (blank solvent). Gas chromatography-mass spectrometry (GC-MS) identified significant metabolic disturbances in all tissues. Specifically, 24, 15, 12, 21, 35, 26, 18, and 28 differential metabolites were detected in the lungs, heart, stomach, blood, spleen, intestine, liver, and kidneys, respectively. |
| Organism | Mus musculus |
| Data Type | Metabolome Data by Mass Spectrometry (MS) |
| Data Accessibility | Open-access |
| BioProject | PRJCA037948 |
| Release Date | 2025-05-26 |
| Submitter | xiaodong ZHU (zxdsawq@126.com) |
| Organization | Affiliated Hospital of Jining Medical University |
| Submission Date | 2025-03-28 |
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| File ID | File Title | Number/Samples | File Type | File Size | File Suffix | Download |
|---|---|---|---|---|---|---|
| OMIX009615-01 | spleen | 23 | Metabolome Data by Mass Spectrometry (MS) | 476.65 MB | zip | |
| OMIX009615-02 | kidney | 28 | Metabolome Data by Mass Spectrometry (MS) | 638.96 MB | zip | |
| OMIX009615-03 | intestine | 24 | Metabolome Data by Mass Spectrometry (MS) | 428.51 MB | zip | |
| OMIX009615-04 | heart | 23 | Metabolome Data by Mass Spectrometry (MS) | 516.92 MB | zip | |
| OMIX009615-05 | blood | 22 | Metabolome Data by Mass Spectrometry (MS) | 422.13 MB | zip | |
| OMIX009615-06 | liver | 23 | Metabolome Data by Mass Spectrometry (MS) | 538.89 MB | zip | |
| OMIX009615-07 | stomach | 23 | Metabolome Data by Mass Spectrometry (MS) | 447.16 MB | zip | |
| OMIX009615-08 | lung | 23 | Metabolome Data by Mass Spectrometry (MS) | 456.34 MB | zip |
| Paper Title | Journal Name | Publish Time | Accession | Citing Type |
|---|---|---|---|---|
| Comprehensive metabolomics study identifies SN-38 organ specific toxicity in mice | Scientific Reports | 2025-05 | OMIX009615 | Deposit |