| Title | Targeted omics analysis of liver energy metabolism in C57BL mice after Escherichia coli infection |
|---|---|
| Description | Metabolic reprogramming is an important adaptive mechanism for the host to resist infection. To clarify the energy metabolism regulation in programmed cell death induced by E.coli. We conducted targeted omics analysis of energy metabolism in the liver of mice. After infection, the levels of acetyl-COA, Citrate, cis-aconitate, Isocitrate and α -ketoglutarate in the TCA cycle were all upregulated, while succinyl-COA and Succinate were downregulated. Meanwhile, the content of the anti-inflammatory metabolite Itaconic acid increased sharply, suggesting that this metabolic reprogramming may have both anti-infection and cell fate regulation functions. |
| Organism | Mus musculus |
| Data Type | Metabolome Data by Mass Spectrometry (MS) |
| Data Accessibility | Open-access |
| BioProject | PRJCA039144 |
| Release Date | 2025-04-23 |
| Submitter | hao Wang (wanghaoxu0117@163.com) |
| Organization | Yunnan Agricultural University |
| Submission Date | 2025-04-22 |
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| File ID | File Title | Number/Samples | File Type | File Size | File Suffix | Download |
|---|---|---|---|---|---|---|
| OMIX009912-01 | T-1 | 1 | Metabolome Data by Mass Spectrometry (MS) | 233.24 KB | tar.gz | |
| OMIX009912-02 | NC-5 | 1 | Metabolome Data by Mass Spectrometry (MS) | 232.9 KB | tar.gz | |
| OMIX009912-03 | T-5 | 1 | Metabolome Data by Mass Spectrometry (MS) | 232.82 KB | tar.gz | |
| OMIX009912-04 | NC-2 | 1 | Metabolome Data by Mass Spectrometry (MS) | 232.76 KB | tar.gz | |
| OMIX009912-05 | NC-6 | 1 | Metabolome Data by Mass Spectrometry (MS) | 234.05 KB | tar.gz | |
| OMIX009912-06 | NC-4 | 1 | Metabolome Data by Mass Spectrometry (MS) | 233.36 KB | tar.gz | |
| OMIX009912-07 | NC-1 | 1 | Metabolome Data by Mass Spectrometry (MS) | 234.01 KB | tar.gz | |
| OMIX009912-08 | T-2 | 1 | Metabolome Data by Mass Spectrometry (MS) | 231.88 KB | tar.gz | |
| OMIX009912-09 | T-6 | 1 | Metabolome Data by Mass Spectrometry (MS) | 232.69 KB | tar.gz |
| Paper Title | Journal Name | Publish Time | Accession | Citing Type |
|---|---|---|---|---|
| Acetylated mitochondrial MDH2 regulates CTR2 transcription to induce cuproptosis during Escherichia coli infection | Nature Communications | 2026-05 | OMIX009912 OMIX009962 | Deposit |