| Title | Neutrophil and PBMC gene expression in adult-onset Still's disease |
|---|---|
| Description | Macrophage activation syndrome (MAS) is believed to be the result of inappropriate proliferation and activation of the mononuclear phagocytic system. As a life-threatening complication of adult-onset Still's disease (AOSD), MAS develops in the context of excessive neutrophil activation and a fulminant cytokine storm. The role of immune cells in driving this hyperinflammation requires further investigation. |
| Organism | Homo sapiens |
| Data Type | Expression Profiling |
| Data Accessibility | Controlled-access |
| BioProject | PRJCA039253 |
| Release Date | 2025-06-24 |
| Submitter | Qiongyi Hu (hqy12436@rjh.com.cn) |
| Organization | Ruijin Hospital, Shanghai jiaotong University School of Medicine |
| Submission Date | 2025-04-24 |
The data cannot be downloaded as it has not yet been registered in the Human Genetic Resource Management Platform of MOST.
| File ID | File Title | Number/Samples | File Type | File Size | File Suffix | Download |
|---|---|---|---|---|---|---|
| OMIX009959-01 | Readcount PBMC and Neutrophil of 7MAS | 14 | Expression Profiling | 1.7 MB | xls | Unavailable |
| OMIX009959-02 | Readcount Neutrophil of 6 nonMAS vs 7 MAS | 13 | Expression Profiling | 1.7 MB | xls | Unavailable |
| OMIX009959-03 | Readcount Neutrophil of 3 MAS pre-rux and post-rux | 6 | Expression Profiling | 1.4 MB | xls | Unavailable |
| OMIX009959-04 | Readcount PBMC of 3 MAS pre-rux and post-rux | 6 | Expression Profiling | 1.4 MB | xls | Unavailable |
| Paper Title | Journal Name | Publish Time | Accession | Citing Type |
|---|---|---|---|---|
| Ruxolitinib Targets JAK-STAT Signaling to Modulate Neutrophil Activation in Refractory Macrophage Activation Syndrome | Blood | 2025-05 | OMIX009959 | Deposit |