OMIX009983

1Summary

Title	Targeting branched-chain amino acids alleviates pulmonary fibrosis
Description	Idiopathic pulmonary fibrosis (IPF) is a devastating, progressive interstitial lung disease characterized by relentless scarring of the lung parenchyma, leading to irreversible decline of lung function and a poor prognosis. Despite extensive research, the molecular mechanisms driving lung fibroblast activation and fibrosis remain incompletely understood. Emerging evidence highlights the pivotal role of cellular metabolism in regulating cellular function and disease progression. In this study, we employed metabolic profilings using ex vivo lung fibroblasts and in vivo rodent models of IPF. MLFs treated with 20 ng/mL TGF-β1 for 48 h were used as in vitro model for pulmonary fibrosis. Mice intratracheally injected with 1.25 mg/kg bleomycin (BLM) for 21 days were used as in vivo model for pulmonary fibrosis. Chromatographic separation was performed using an Agilent 1290II ultra-high-pressure liquid chromatography (UHPLC) system equipped with 6546 quadrupole time-of-flight (QTOF) mass spectrometry.
Organism	Mus musculus
Data Type	Metabolome Data by Mass Spectrometry (MS)
Data Accessibility	Open-access
BioProject	PRJCA039413
Release Date	2026-03-17
Submitter	Jie Yao (yaojie@whu.edu.cn)
Organization	Guangzhou National Laboratory
Submission Date	2025-04-27

2Files & Download

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File ID	File Title	Number/Samples	File Type	File Size	File Suffix	Download
OMIX009983-01	tissue_PBS_7_neg	1	Metabolome Data by Mass Spectrometry (MS)	104.46 MB	d.zip	FTP HTTPs
OMIX009983-02	tissue_PBS_6_pos	1	Metabolome Data by Mass Spectrometry (MS)	137.19 MB	d.zip	FTP HTTPs
OMIX009983-03	tissue_BLM_2_pos	1	Metabolome Data by Mass Spectrometry (MS)	138.35 MB	d.zip	FTP HTTPs
OMIX009983-04	tissue_PBS_6_neg	1	Metabolome Data by Mass Spectrometry (MS)	104.46 MB	d.zip	FTP HTTPs
OMIX009983-05	tissue_BLM_6_neg	1	Metabolome Data by Mass Spectrometry (MS)	104.63 MB	d.zip	FTP HTTPs
OMIX009983-06	tissue_BLM_4_neg	1	Metabolome Data by Mass Spectrometry (MS)	104.36 MB	d.zip	FTP HTTPs
OMIX009983-07	tissue_BLM_7_neg	1	Metabolome Data by Mass Spectrometry (MS)	105.42 MB	d.zip	FTP HTTPs
OMIX009983-08	tissue_PBS_1_neg	1	Metabolome Data by Mass Spectrometry (MS)	104.82 MB	d.zip	FTP HTTPs
OMIX009983-09	tissue_PBS_2_pos	1	Metabolome Data by Mass Spectrometry (MS)	137.13 MB	d.zip	FTP HTTPs
OMIX009983-10	tissue_PBS_7_pos	1	Metabolome Data by Mass Spectrometry (MS)	137.04 MB	d.zip	FTP HTTPs
OMIX009983-11	tissue_PBS_1_pos	1	Metabolome Data by Mass Spectrometry (MS)	136.89 MB	d.zip	FTP HTTPs
OMIX009983-12	tissue_PBS_2_neg	1	Metabolome Data by Mass Spectrometry (MS)	104.78 MB	d.zip	FTP HTTPs
OMIX009983-13	tissue_BLM_7_pos	1	Metabolome Data by Mass Spectrometry (MS)	138.16 MB	d.zip	FTP HTTPs
OMIX009983-14	tissue_BLM_5_pos	1	Metabolome Data by Mass Spectrometry (MS)	137.57 MB	d.zip	FTP HTTPs
OMIX009983-15	tissue_PBS_3_pos	1	Metabolome Data by Mass Spectrometry (MS)	137.21 MB	d.zip	FTP HTTPs
OMIX009983-16	tissue_BLM_6_pos	1	Metabolome Data by Mass Spectrometry (MS)	137.91 MB	d.zip	FTP HTTPs
OMIX009983-17	tissue_BLM_1_pos	1	Metabolome Data by Mass Spectrometry (MS)	138.04 MB	d.zip	FTP HTTPs
OMIX009983-18	tissue_PBS_5_pos	1	Metabolome Data by Mass Spectrometry (MS)	136.91 MB	d.zip	FTP HTTPs
OMIX009983-19	tissue_PBS_5_neg	1	Metabolome Data by Mass Spectrometry (MS)	104.63 MB	d.zip	FTP HTTPs
OMIX009983-20	tissue_BLM_2_neg	1	Metabolome Data by Mass Spectrometry (MS)	104.22 MB	d.zip	FTP HTTPs
OMIX009983-21	tissue_PBS_4_pos	1	Metabolome Data by Mass Spectrometry (MS)	137.21 MB	d.zip	FTP HTTPs
OMIX009983-22	tissue_BLM_5_neg	1	Metabolome Data by Mass Spectrometry (MS)	104.66 MB	d.zip	FTP HTTPs
OMIX009983-23	tissue_PBS_4_neg	1	Metabolome Data by Mass Spectrometry (MS)	105.3 MB	d.zip	FTP HTTPs
OMIX009983-24	tissue_BLM_3_pos	1	Metabolome Data by Mass Spectrometry (MS)	138 MB	d.zip	FTP HTTPs
OMIX009983-25	tissue_BLM_4_pos	1	Metabolome Data by Mass Spectrometry (MS)	137.73 MB	d.zip	FTP HTTPs
OMIX009983-26	tissue_BLM_3_neg	1	Metabolome Data by Mass Spectrometry (MS)	104.87 MB	d.zip	FTP HTTPs
OMIX009983-27	tissue_PBS_3_neg	1	Metabolome Data by Mass Spectrometry (MS)	104.71 MB	d.zip	FTP HTTPs
OMIX009983-28	tissue_BLM_1_neg	1	Metabolome Data by Mass Spectrometry (MS)	104.42 MB	d.zip	FTP HTTPs
OMIX009983-29	cell_TGF2_neg	1	Metabolome Data by Mass Spectrometry (MS)	104.56 MB	d.zip	FTP HTTPs
OMIX009983-30	cell_TGF1_pos	1	Metabolome Data by Mass Spectrometry (MS)	137.28 MB	d.zip	FTP HTTPs
OMIX009983-31	cell_TGF3_neg	1	Metabolome Data by Mass Spectrometry (MS)	104.6 MB	d.zip	FTP HTTPs
OMIX009983-32	cell_TGF1_neg	1	Metabolome Data by Mass Spectrometry (MS)	104.5 MB	d.zip	FTP HTTPs
OMIX009983-33	cell_TGF3_pos	1	Metabolome Data by Mass Spectrometry (MS)	137.31 MB	d.zip	FTP HTTPs
OMIX009983-34	cell_PBS2_neg	1	Metabolome Data by Mass Spectrometry (MS)	104.71 MB	d.zip	FTP HTTPs
OMIX009983-35	cell_PBS1_pos	1	Metabolome Data by Mass Spectrometry (MS)	137.47 MB	d.zip	FTP HTTPs
OMIX009983-36	cell_PBS3_neg	1	Metabolome Data by Mass Spectrometry (MS)	104.71 MB	d.zip	FTP HTTPs
OMIX009983-37	cell_PBS3_pos	1	Metabolome Data by Mass Spectrometry (MS)	137.4 MB	d.zip	FTP HTTPs
OMIX009983-38	cell_TGF2_pos	1	Metabolome Data by Mass Spectrometry (MS)	137.34 MB	d.zip	FTP HTTPs
OMIX009983-39	cell_PBS2_pos	1	Metabolome Data by Mass Spectrometry (MS)	137.45 MB	d.zip	FTP HTTPs
OMIX009983-40	cell_PBS1_neg	1	Metabolome Data by Mass Spectrometry (MS)	104.74 MB	d.zip	FTP HTTPs

3Relevant Publications

Paper Title	Journal Name	Publish Time	Accession	Citing Type
Dietary intake and BCAA metabolism regulate pulmonary fibrosis through KDM4A-mediated epigenetic remodeling in male mice	Nature Communications	2026-04	OMIX009983	Deposit

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