| Title | Multi-omics determination of senescence markers in MSCs |
|---|---|
| Description | Dogs serve as ideal research subjects for aging studies.In this study, 9 aging-related cell populations were identified through single-cell RNA sequencing of dogs of different ages. Additionally, 9 CD8+ T cell senescence-specific markers that are conserved across species were identified. Furthermore, this study employed multi-omics technology to characterize 17 transcriptional and protein markers, along with 5 metabolic markers, associated with stem cell aging. This study further validated Penitrem A and UDP-N-acetylglucosamine as two consistent metabolic markers of both individual and cellular senescence. |
| Organism | Canis lupus familiaris |
| Data Type | Proteomic Data by Mass Spectrometry (MS) |
| Data Accessibility | Open-access |
| BioProject | PRJCA039949 |
| Release Date | 2025-05-30 |
| Submitter | Balun Li (libalun@nwafu.edu.cn) |
| Organization | Northwest A F University |
| Submission Date | 2025-05-09 |
HTTP download speed may be slow. It is highly recommended that you download the dataset using a dedicated FTP tool (such as FileZilla Client).
| File ID | File Title | Number/Samples | File Type | File Size | File Suffix | Download |
|---|---|---|---|---|---|---|
| OMIX010111-01 | Proteomics of aging in MSCs | 13 | Proteomic Data by Mass Spectrometry (MS) | 19.15 GB | zip |
| Paper Title | Journal Name | Publish Time | Accession | Citing Type |
|---|---|---|---|---|
| Multi-omics analysis of canine aging markers and evaluation of stem cell intervention | Communications Biology | 2025-06 | OMIX010212 OMIX010110 OMIX010111 | Deposit |