| Title | An iPSC-derived CD19/BCMA-targeting CAR-NK therapy induced immune reset in refractory systemic sclerosis |
|---|---|
| Description | This project reports the first clinical application of iPSC-derived, CD19/BCMA dual-targeting CAR-NK cells (QN-139b) for the treatment of severe diffuse cutaneous systemic sclerosis (dcSSc). The allogeneic product was extensively engineered to minimize immunogenicity and enhance in vivo efficacy, with scalable manufacturing enabled by clonal expansion of iPSCs. In the treated patient, QN-139b was well-tolerated and induced profound B cell depletion alongside marked clinical improvements, including reductions in fibrosis and autoantibody levels. Integrated multi-omics and histopathological analyses revealed immune modulation, reversal of fibrosis, and tissue regeneration. These findings position QN-139b as a promising cell-based immunotherapy for treatment-resistant autoimmune diseases. |
| Organism | Homo sapiens |
| Data Type | Expression Profiling |
| Data Accessibility | Controlled-access |
| BioProject | PRJCA040376 |
| Release Date | 2025-05-20 |
| Submitter | Xiaobing Wang (gale820907@163.com) |
| Organization | Second Affiliated Hospital of Naval Medical University |
| Submission Date | 2025-05-20 |
The data cannot be downloaded as it has not yet been registered in the Human Genetic Resource Management Platform of MOST.
| File ID | File Title | Number/Samples | File Type | File Size | File Suffix | Download |
|---|---|---|---|---|---|---|
| OMIX010241-01 | PBMC scRNA-seq at baseline | 5 | Expression Profiling | 53.1 MB | zip | Unavailable |
| OMIX010241-02 | PBMC scRNA-seq at M1 | 5 | Expression Profiling | 87.9 MB | zip | Unavailable |
| OMIX010241-03 | PBMC scRNA-seq at M2 | 5 | Expression Profiling | 67.9 MB | zip | Unavailable |
| OMIX010241-04 | PBMC scRNA-seq at M3 | 5 | Expression Profiling | 70.4 MB | zip | Unavailable |
| Paper Title | Journal Name | Publish Time | Accession | Citing Type |
|---|---|---|---|---|
| An iPSC-derived CD19/BCMA CAR-NK therapy in a patient with systemic sclerosis | Cell | 2025-06 | OMIX010240 OMIX010241 | Deposit |