| Title | scRNAseq data of a mechano-resistance mechanism in skin adapts to terrestrial locomotion |
|---|---|
| Description | We identify an evolutionarily emerged mechanism in skin epithelial cells that adapts to this mechanical demand. We show that the Slurp1 gene, conserved across tetrapods, is specifically expressed in palmoplantar skin. In humans, mutations in SLURP1 cause palmoplantar keratoderma (PPK), a condition marked by thickened skin epidermis on the soles and palms. Remarkably, reducing mechanical pressure on Slurp1 knockout paw skin fully rescues the PPK phenotype. Mechanistically, SLURP1 localizes to the endoplasmic reticulum (ER) membrane, where it binds the calcium pump SERCA2b. By preserving SERCA2b activity under mechanical pressure, SLURP1 maintains low cytoplasmic calcium levels and inhibits pressure-induced activation of the pPERK-NRF2 signaling, a pathway that can be genetically targeted to reverse PPK. These findings reveal an ER-based mechano-resistance mechanism that enhances cellular defence against prolonged mechanical pressure. |
| Organism | Mus musculus |
| Data Type | Expression Profiling |
| Data Accessibility | Open-access |
| BioProject | PRJCA042267 |
| Release Date | 2025-08-13 |
| Submitter | Ting C (chenting@nibs.ac.cn) |
| Organization | National Institute of Biological Sciences, Beijing |
| Submission Date | 2025-06-27 |
HTTP download speed may be slow. It is highly recommended that you download the dataset using a dedicated FTP tool (such as FileZilla Client).
| File ID | File Title | Number/Samples | File Type | File Size | File Suffix | Download |
|---|---|---|---|---|---|---|
| OMIX010781-01 | scRNAseq of paw epidermis from WT mouse at P43 | 1 | Expression Profiling | 90.71 MB | tar | |
| OMIX010781-02 | scRNAseq of paw epidermis from WT mouse at P28 | 1 | Expression Profiling | 99.08 MB | tar | |
| OMIX010781-03 | scRNAseq of paw epidermis from Slurp1 KO mouse at P28 | 1 | Expression Profiling | 140.48 MB | tar | |
| OMIX010781-04 | scRNAseq of paw epidermis from Slurp1 KO mouse at P63 | 1 | Expression Profiling | 68.21 MB | tar | |
| OMIX010781-05 | scRNAseq of paw epidermis from WT mouse at P63 | 1 | Expression Profiling | 133.41 MB | tar | |
| OMIX010781-06 | scRNAseq of paw epidermis from Slurp1 KO mouse at P43 | 1 | Expression Profiling | 128.46 MB | tar |
| Paper Title | Journal Name | Publish Time | Accession | Citing Type |
|---|---|---|---|---|
| A mechano-resistance mechanism in skin adapts to terrestrial locomotion | Cell | 2025-10 | OMIX010781 | Deposit |