OMIX011155

1Summary

Title	FAT-5/SCD5 mediated lipid localization in lysosomes alleviates gamma-radiation injury in Caenorhabditis elegans
Description	This study discovered that Caenorhabditis elegans can withstand high-dose radiation when pre-exposed to low temperatures (4°C) for 4 hours. The metabolites released by C. elegans target guanylyl cyclase GCY-5, which reduces lysosome acidification and enhances lipid translocation via FAT-5/SCD5, mitigating radiation damage.
Organism	Caenorhabditis elegans
Data Type	Lipidome Data by Mass Spectrometry (MS)
Data Accessibility	Open-access
BioProject	PRJCA043624
Release Date	2025-08-19
Submitter	Tong Zhu (zhutong@irm-cams.ac.cn)
Organization	Institute of Radiation Medicine, Chinese Academy of Medical Sciences
Submission Date	2025-07-24

2Files & Download

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File ID	File Title	Number/Samples	File Type	File Size	File Suffix	Download
OMIX011155-01	gcy-5 deficient worms under irradiation at 60Gy, Repeat 4, Postive	1	Lipidome Data by Mass Spectrometry (MS)	102.58 MB	raw	FTP HTTPs
OMIX011155-02	WT worms under irradiation at 60Gy, Repeat 6, Negative	1	Lipidome Data by Mass Spectrometry (MS)	63.51 MB	raw	FTP HTTPs
OMIX011155-03	WT worms under irradiation at 60Gy, Repeat 2, Negative	1	Lipidome Data by Mass Spectrometry (MS)	63.49 MB	raw	FTP HTTPs
OMIX011155-04	Quality Control Sample, Repeat 2, Positive	1	Lipidome Data by Mass Spectrometry (MS)	103.8 MB	raw	FTP HTTPs
OMIX011155-05	Quality Control Sample, Repeat 2, Negative	1	Lipidome Data by Mass Spectrometry (MS)	63.19 MB	raw	FTP HTTPs
OMIX011155-06	WT worms under irradiation at 60Gy, Repeat 4, Positive	1	Lipidome Data by Mass Spectrometry (MS)	104.39 MB	raw	FTP HTTPs
OMIX011155-07	WT worms under irradiation at 60Gy, Repeat 2, Positive	1	Lipidome Data by Mass Spectrometry (MS)	103.41 MB	raw	FTP HTTPs
OMIX011155-08	WT worms under irradiation at 60Gy, Repeat 3, Positive	1	Lipidome Data by Mass Spectrometry (MS)	103.07 MB	raw	FTP HTTPs
OMIX011155-09	gcy-5 deficient worms under irradiation at 60Gy, Repeat 2, Negative	1	Lipidome Data by Mass Spectrometry (MS)	62.87 MB	raw	FTP HTTPs
OMIX011155-10	gcy-5 deficient worms under irradiation at 60Gy, Repeat 6, Negative	1	Lipidome Data by Mass Spectrometry (MS)	62.88 MB	raw	FTP HTTPs
OMIX011155-11	WT worms under irradiation at 60Gy, Repeat 4, Negative	1	Lipidome Data by Mass Spectrometry (MS)	63.19 MB	raw	FTP HTTPs
OMIX011155-12	Quality control sample, repeat 3, negative	1	Lipidome Data by Mass Spectrometry (MS)	63.23 MB	raw	FTP HTTPs
OMIX011155-13	WT worms under irradiation at 60Gy, repeat 1, positive	1	Lipidome Data by Mass Spectrometry (MS)	104.19 MB	raw	FTP HTTPs
OMIX011155-14	gcy-5 deficient worms under irradiation at 60Gy, repeat 6, positive	1	Lipidome Data by Mass Spectrometry (MS)	103.87 MB	raw	FTP HTTPs
OMIX011155-15	gcy-5 deficient worms under irradiation at 60Gy, repeat 4, negative	1	Lipidome Data by Mass Spectrometry (MS)	61.83 MB	raw	FTP HTTPs
OMIX011155-16	gcy-5 deficient worms under irradiation at 60Gy, repeat 1, positive	1	Lipidome Data by Mass Spectrometry (MS)	103.81 MB	raw	FTP HTTPs
OMIX011155-17	WT worms under irradiation at 60Gy, repeat 3, negative	1	Lipidome Data by Mass Spectrometry (MS)	62.62 MB	raw	FTP HTTPs
OMIX011155-18	WT worms under irradiation at 60Gy, repeat 5, positive	1	Lipidome Data by Mass Spectrometry (MS)	103.35 MB	raw	FTP HTTPs
OMIX011155-19	gcy-5 deficient worms under irradiation at 60Gy, repeat 3, negative	1	Lipidome Data by Mass Spectrometry (MS)	62.35 MB	raw	FTP HTTPs
OMIX011155-20	gcy-5 deficient worms under irradiation at 60Gy, repeat 1, negative	1	Lipidome Data by Mass Spectrometry (MS)	62.18 MB	raw	FTP HTTPs
OMIX011155-21	WT worms under irradiation at 60Gy, repeat 5, negative	1	Lipidome Data by Mass Spectrometry (MS)	63.24 MB	raw	FTP HTTPs
OMIX011155-22	Quality control sample, repeat 1, positive	1	Lipidome Data by Mass Spectrometry (MS)	103.95 MB	raw	FTP HTTPs
OMIX011155-23	WT worms under irradiation at 60Gy, repeat 1, negative	1	Lipidome Data by Mass Spectrometry (MS)	64.14 MB	raw	FTP HTTPs
OMIX011155-24	gcy-5 deficient worms under irradiation at 60Gy, repeat 5, positive	1	Lipidome Data by Mass Spectrometry (MS)	102.64 MB	raw	FTP HTTPs
OMIX011155-25	WT worms under irradiation at 60Gy, repeat 6, positive	1	Lipidome Data by Mass Spectrometry (MS)	104.23 MB	raw	FTP HTTPs
OMIX011155-26	Quality control sample, repeat 1, negative	1	Lipidome Data by Mass Spectrometry (MS)	62.88 MB	raw	FTP HTTPs
OMIX011155-27	Quality control sample, repeat 3, positive	1	Lipidome Data by Mass Spectrometry (MS)	103.72 MB	raw	FTP HTTPs
OMIX011155-28	gcy-5 deficient worms under irradiation at 60Gy, repeat 3, positive	1	Lipidome Data by Mass Spectrometry (MS)	103.97 MB	raw	FTP HTTPs
OMIX011155-29	gcy-5 deficient worms under irradiation at 60Gy, repeat 2, positive	1	Lipidome Data by Mass Spectrometry (MS)	103.87 MB	raw	FTP HTTPs
OMIX011155-30	gcy-5 deficient worms under irradiation at 60Gy, repeat 5, negative	1	Lipidome Data by Mass Spectrometry (MS)	62.61 MB	raw	FTP HTTPs

3Relevant Publications

Paper Title	Journal Name	Publish Time	Accession	Citing Type
FAT-5/SCD5 -mediated lipid localization in lysosomes alleviates gamma radiation injury in Caenorhabditis elegans	The Journal of Biological Chemistry	2025-09	OMIX011155	Deposit

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