OMIX011761

1Summary

Title	Plasma Proteome-Driven Liquid Biopsy for Individualized Monitoring and Risk Stratification of Immune-Related Adverse Events in Checkpoint Immunotherapy
Description	Immune checkpoint inhibitors (ICIs) have revolutionized cancer therapy, but their associated immune-related adverse events (irAEs) pose significant clinical challenges to patient management and outcomes. Here, we conducted a comprehensive mass spectrometry-based discovery-validation proteomic profiling analysis to explore plasma proteomic biomarkers for the prediction and monitoring of irAEs in patients receiving ICI treatment.
Organism	Homo sapiens
Data Type	Proteomic Data by Mass Spectrometry (MS)
Data Accessibility	Open-access
BioProject	PRJCA033914
Release Date	2025-10-29
Submitter	Zhou Meng (zhoumeng@wmu.edu.cn)
Organization	Wenzhou Medical University
Submission Date	2025-09-04

2Files & Download

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File ID	File Title	Number/Samples	File Type	File Size	File Suffix	Download
OMIX011761-01	XB05807DA_SS1_5.raw	1	Proteomic Data by Mass Spectrometry (MS)	265.37 MB	raw	FTP HTTPs
OMIX011761-02	XB05807DA_SS1_6.raw	1	Proteomic Data by Mass Spectrometry (MS)	237 MB	raw	FTP HTTPs
OMIX011761-03	XB05807DA_SS1_3.raw	1	Proteomic Data by Mass Spectrometry (MS)	243.45 MB	raw	FTP HTTPs
OMIX011761-04	XB05807DA_SS1_4.raw	1	Proteomic Data by Mass Spectrometry (MS)	251.76 MB	raw	FTP HTTPs
OMIX011761-05	XB05807DA_SS1_2.raw	1	Proteomic Data by Mass Spectrometry (MS)	257.19 MB	raw	FTP HTTPs
OMIX011761-06	XB05807DA_SS1_1.raw	1	Proteomic Data by Mass Spectrometry (MS)	277.61 MB	raw	FTP HTTPs
OMIX011761-07	XB05807DA_CS1_5.raw	1	Proteomic Data by Mass Spectrometry (MS)	245.83 MB	raw	FTP HTTPs
OMIX011761-08	XB05807DA_CS1_4.raw	1	Proteomic Data by Mass Spectrometry (MS)	238.99 MB	raw	FTP HTTPs
OMIX011761-09	XB05807DA_CS1_3.raw	1	Proteomic Data by Mass Spectrometry (MS)	239.4 MB	raw	FTP HTTPs
OMIX011761-10	XB05807DA_CS1_2.raw	1	Proteomic Data by Mass Spectrometry (MS)	228.21 MB	raw	FTP HTTPs
OMIX011761-11	XB05807DA_CS1_1.raw	1	Proteomic Data by Mass Spectrometry (MS)	240.41 MB	raw	FTP HTTPs
OMIX011761-12	XB05807DA_CC1_7.raw	1	Proteomic Data by Mass Spectrometry (MS)	241.34 MB	raw	FTP HTTPs
OMIX011761-13	XB05807DA_CC1_5.raw	1	Proteomic Data by Mass Spectrometry (MS)	233.66 MB	raw	FTP HTTPs
OMIX011761-14	XB05807DA_CC1_6.raw	1	Proteomic Data by Mass Spectrometry (MS)	243.87 MB	raw	FTP HTTPs
OMIX011761-15	XB05807DA_CC1_4.raw	1	Proteomic Data by Mass Spectrometry (MS)	237.24 MB	raw	FTP HTTPs
OMIX011761-16	XB05807DA_CC1_3.raw	1	Proteomic Data by Mass Spectrometry (MS)	233.37 MB	raw	FTP HTTPs
OMIX011761-17	XB05807DA_CC1_2.raw	1	Proteomic Data by Mass Spectrometry (MS)	228.38 MB	raw	FTP HTTPs
OMIX011761-18	XB05807DA_CC1_1.raw	1	Proteomic Data by Mass Spectrometry (MS)	238.29 MB	raw	FTP HTTPs
OMIX011761-19	XA00974DA_S_22.raw	1	Proteomic Data by Mass Spectrometry (MS)	369.82 MB	raw	FTP HTTPs
OMIX011761-20	XA00974DA_S_21.raw	1	Proteomic Data by Mass Spectrometry (MS)	354.5 MB	raw	FTP HTTPs
OMIX011761-21	XA00974DA_S_19.raw	1	Proteomic Data by Mass Spectrometry (MS)	352.42 MB	raw	FTP HTTPs
OMIX011761-22	XA00974DA_S_20.raw	1	Proteomic Data by Mass Spectrometry (MS)	356.23 MB	raw	FTP HTTPs
OMIX011761-23	XA00974DA_S_17.raw	1	Proteomic Data by Mass Spectrometry (MS)	358.5 MB	raw	FTP HTTPs
OMIX011761-24	XA00974DA_S_18.raw	1	Proteomic Data by Mass Spectrometry (MS)	344.66 MB	raw	FTP HTTPs
OMIX011761-25	XA00974DA_S_15.raw	1	Proteomic Data by Mass Spectrometry (MS)	395.41 MB	raw	FTP HTTPs
OMIX011761-26	XA00974DA_S_16.raw	1	Proteomic Data by Mass Spectrometry (MS)	361.84 MB	raw	FTP HTTPs
OMIX011761-27	XA00974DA_S_14.raw	1	Proteomic Data by Mass Spectrometry (MS)	412.59 MB	raw	FTP HTTPs
OMIX011761-28	XA00974DA_S_13.raw	1	Proteomic Data by Mass Spectrometry (MS)	359.26 MB	raw	FTP HTTPs
OMIX011761-29	XA00974DA_S_11.raw	1	Proteomic Data by Mass Spectrometry (MS)	363.43 MB	raw	FTP HTTPs
OMIX011761-30	XA00974DA_S_12.raw	1	Proteomic Data by Mass Spectrometry (MS)	360.51 MB	raw	FTP HTTPs
OMIX011761-31	XA00974DA_S_10.raw	1	Proteomic Data by Mass Spectrometry (MS)	346.81 MB	raw	FTP HTTPs
OMIX011761-32	XA00974DA_S_09.raw	1	Proteomic Data by Mass Spectrometry (MS)	352.51 MB	raw	FTP HTTPs
OMIX011761-33	XA00974DA_S_08.raw	1	Proteomic Data by Mass Spectrometry (MS)	363.83 MB	raw	FTP HTTPs
OMIX011761-34	XA00974DA_S_07.raw	1	Proteomic Data by Mass Spectrometry (MS)	372.77 MB	raw	FTP HTTPs
OMIX011761-35	XA00974DA_S_05.raw	1	Proteomic Data by Mass Spectrometry (MS)	345.93 MB	raw	FTP HTTPs
OMIX011761-36	XA00974DA_S_06.raw	1	Proteomic Data by Mass Spectrometry (MS)	362.85 MB	raw	FTP HTTPs
OMIX011761-37	XA00974DA_S_03.raw	1	Proteomic Data by Mass Spectrometry (MS)	375.8 MB	raw	FTP HTTPs
OMIX011761-38	XA00974DA_S_04.raw	1	Proteomic Data by Mass Spectrometry (MS)	340.14 MB	raw	FTP HTTPs
OMIX011761-39	XA00974DA_S_02.raw	1	Proteomic Data by Mass Spectrometry (MS)	358.79 MB	raw	FTP HTTPs
OMIX011761-40	XA00974DA_M_14.raw	1	Proteomic Data by Mass Spectrometry (MS)	359.9 MB	raw	FTP HTTPs
OMIX011761-41	XA00974DA_S_01.raw	1	Proteomic Data by Mass Spectrometry (MS)	353.91 MB	raw	FTP HTTPs
OMIX011761-42	XA00974DA_M_13.raw	1	Proteomic Data by Mass Spectrometry (MS)	367.69 MB	raw	FTP HTTPs
OMIX011761-43	XA00974DA_M_12.raw	1	Proteomic Data by Mass Spectrometry (MS)	355.91 MB	raw	FTP HTTPs
OMIX011761-44	XA00974DA_M_11.raw	1	Proteomic Data by Mass Spectrometry (MS)	354.5 MB	raw	FTP HTTPs
OMIX011761-45	XA00974DA_M_10.raw	1	Proteomic Data by Mass Spectrometry (MS)	364.44 MB	raw	FTP HTTPs
OMIX011761-46	XA00974DA_M_09.raw	1	Proteomic Data by Mass Spectrometry (MS)	369.66 MB	raw	FTP HTTPs
OMIX011761-47	XA00974DA_M_08.raw	1	Proteomic Data by Mass Spectrometry (MS)	385.99 MB	raw	FTP HTTPs
OMIX011761-48	XA00974DA_M_07.raw	1	Proteomic Data by Mass Spectrometry (MS)	379.56 MB	raw	FTP HTTPs
OMIX011761-49	XA00974DA_M_06.raw	1	Proteomic Data by Mass Spectrometry (MS)	366.01 MB	raw	FTP HTTPs
OMIX011761-50	XA00974DA_M_05.raw	1	Proteomic Data by Mass Spectrometry (MS)	351.68 MB	raw	FTP HTTPs
OMIX011761-51	XA00974DA_M_04.raw	1	Proteomic Data by Mass Spectrometry (MS)	355.54 MB	raw	FTP HTTPs
OMIX011761-52	XA00974DA_M_03.raw	1	Proteomic Data by Mass Spectrometry (MS)	357.53 MB	raw	FTP HTTPs
OMIX011761-53	XA00974DA_M_02.raw	1	Proteomic Data by Mass Spectrometry (MS)	361.77 MB	raw	FTP HTTPs
OMIX011761-54	XA00974DA_M_01.raw	1	Proteomic Data by Mass Spectrometry (MS)	368 MB	raw	FTP HTTPs
OMIX011761-55	XA00974DA_C_11.raw	1	Proteomic Data by Mass Spectrometry (MS)	390.05 MB	raw	FTP HTTPs
OMIX011761-56	XA00974DA_C_10.raw	1	Proteomic Data by Mass Spectrometry (MS)	357.23 MB	raw	FTP HTTPs
OMIX011761-57	XA00974DA_C_09.raw	1	Proteomic Data by Mass Spectrometry (MS)	370.19 MB	raw	FTP HTTPs
OMIX011761-58	XA00974DA_C_08.raw	1	Proteomic Data by Mass Spectrometry (MS)	374.02 MB	raw	FTP HTTPs
OMIX011761-59	XA00974DA_C_07.raw	1	Proteomic Data by Mass Spectrometry (MS)	359.32 MB	raw	FTP HTTPs
OMIX011761-60	XA00974DA_C_06.raw	1	Proteomic Data by Mass Spectrometry (MS)	378.09 MB	raw	FTP HTTPs
OMIX011761-61	XA00974DA_C_05.raw	1	Proteomic Data by Mass Spectrometry (MS)	356.67 MB	raw	FTP HTTPs
OMIX011761-62	XA00974DA_C_04.raw	1	Proteomic Data by Mass Spectrometry (MS)	350.2 MB	raw	FTP HTTPs
OMIX011761-63	XA00974DA_C_03.raw	1	Proteomic Data by Mass Spectrometry (MS)	361.33 MB	raw	FTP HTTPs
OMIX011761-64	XA00974DA_C_02.raw	1	Proteomic Data by Mass Spectrometry (MS)	374.79 MB	raw	FTP HTTPs
OMIX011761-65	XA00974DA_C_01.raw	1	Proteomic Data by Mass Spectrometry (MS)	370.63 MB	raw	FTP HTTPs

3Relevant Publications

Paper Title	Journal Name	Publish Time	Accession	Citing Type
Plasma Proteome-Driven Liquid Biopsy for Individualized Monitoring and Risk Stratification of Immune-Related Adverse Events in Checkpoint Immunotherapy	Molecular & Cellular Proteomics	2025-12	OMIX011761	Deposit

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