| Title |
Spatial multi-omics reveals metabolic features of TREM2-high microglia in the retina |
| Description |
This study investigates the spatial heterogeneity of gene expression and metabolic profiles in ischemic-hypoxic retinas, specifically examining transcriptomic and metabolic perturbations associated with TREM2-high microglia-enriched regions. To address this, we integrated Stereo-seq (spatial transcriptomics) and MALDI imaging mass spectrometry for comprehensive analysis of murine eyes subjected to acute high intraocular pressure injury. |
| Organism |
Mus musculus |
| Data Type |
Metabolome Data by Mass Spectrometry (MS) |
| Data Accessibility |
Open-access |
| BioProject |
PRJCA046665 |
| Release Date |
2026-07-09 |
| Submitter |
HongHua Yu (yuhonghua@gdph.org.cn) |
| Organization |
Guangdong Provincial People's Hospital |
| Submission Date |
2025-09-22 |