| Title | scRNA dataset of ICC |
|---|---|
| Description | METTL5 promotes intrahepatic cholangiocarcinoma (ICC) progression by reshaping the tumor immune microenvironment. METTL5-mediated 18S rRNA m6A modification regulates chemokine translation, affecting CD8+ T cell and macrophage infiltration. Targeting METTL5 with siRNA combined with anti-PD-1 therapy enhances anti-tumor immunity and suppresses ICC growth, identifying METTL5 as a promising therapeutic target for ICC treatment. |
| Organism | Homo sapiens |
| Data Type | Other Type of Genomic Data |
| Data Accessibility | Controlled-access |
| BioProject | PRJCA024070 |
| Release Date | 2025-10-20 |
| Submitter | Ming Kuang (kuangm@mail.sysu.edu.cn) |
| Organization | The First Affiliated Hospital, Sun Yat-sen University |
| Submission Date | 2025-10-03 |
The data cannot be downloaded as it has not yet been registered in the Human Genetic Resource Management Platform of MOST.
| File ID | File Title | Number/Samples | File Type | File Size | File Suffix | Download |
|---|---|---|---|---|---|---|
| OMIX012124-01 | ICC_Tumor_merged.rds | 24 | Other Type of Genomic Data | 4.7 GB | rds | Unavailable |
| Paper Title | Journal Name | Publish Time | Accession | Citing Type |
|---|---|---|---|---|
| METTL5 Enables Immune Evasion of Liver Cancer via Chemokine mRNA Translation Regulation | Advanced Science | 2025-12 | OMIX012124 OMIX012123 | Deposit |