| Title | The Mechanism Study of Intermittent Fasting in Glioblastoma Suppression via Gut Microbiota-mediated m6A Modification |
|---|---|
| Description | Glioblastoma Multiforme (GBM) is one of the most malignant tumors, characterized by high treatment costs and poor outcomes, thus urgently necessitating the development of new therapeutic approaches. Recent studies have found that intermittent fasting (IF) not only can suppress GBM among various tumors but also can reconstruct the gut microbiome and alter metabolism. However, the mechanism by which IF inhibits GBM is not yet fully understood. Using animal models, I discovered that IF can effectively suppress GBM and alter the gut microbiome.Furthermore, microbial metabolites such as methionine, m6A, and the m6A-targeted oncogene TGFB2 were also downregulated. Therefore, we hypothesize that IF, by reconstructing the gut microbiome, reduces the levels of microbial metabolite methionine, subsequently decreasing m6A in GBM, leading to the downregulation of the m6A-targeted oncogene TGFB2, thereby inhibiting the development of GBM. |
| Organism | Mus musculus |
| Data Type | Other Type of Image Data |
| Data Accessibility | Open-access |
| BioProject | PRJCA048431 |
| Release Date | 2025-10-18 |
| Submitter | Yao Lin (223112@sr.gxmu.edu.cn) |
| Organization | Guangxi Medical University |
| Submission Date | 2025-10-16 |
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| File ID | File Title | Number/Samples | File Type | File Size | File Suffix | Download |
|---|---|---|---|---|---|---|
| OMIX012365-01 | Spatial metabolomics 1_smooth_mz (AL) | 1 | Other Type of Image Data | 79.21 MB | rar | |
| OMIX012365-02 | Spatial metabolomics 5_smooth_mz (AL) | 5 | Other Type of Image Data | 76.63 MB | rar | |
| OMIX012365-03 | Spatial metabolomics 14_smooth_mz (IF) | 14 | Other Type of Image Data | 80.28 MB | rar | |
| OMIX012365-04 | Spatial metabolomics 13_smooth_mz (IF) | 13 | Other Type of Image Data | 74.15 MB | rar | |
| OMIX012365-05 | Spatial metabolomics 15_smooth_mz (IF) | 15 | Other Type of Image Data | 82.7 MB | rar | |
| OMIX012365-06 | Spatial metabolomics 3_smooth_mz (AL) | 3 | Other Type of Image Data | 76.29 MB | rar |
| Paper Title | Journal Name | Publish Time | Accession | Citing Type |
|---|---|---|---|---|
| Intermittent fasting inhibits Tp53-driven glioma through gut microbiota-mediated methionine-m 6 A regulation | Nature Communications | 2026-01 | OMIX012365 | Deposit |