| Title | Spatiotemporal Characterization of Skin Lesions in Lupus Erythematosus at Single-cell Resolution |
|---|---|
| Description | Lupus, a severe and complex autoimmune disease, is clinically divided into cutaneous lupus erythematosus (CLE) which featured in skin damage, and systemic lupus erythematosus (SLE) which characterized in systemic multi-organ damage. However, the characteristics and distinctions of the immune microenvironment in lesions of DLE and SLE patients has not been fully understood. Here, we performed spatial transcriptomic sequencing (Stereo-seq) to characterize cellular infiltration and crosstalk in 15 skin biopsies of healthy control(HC), DLE, and SLE, which providing a comprehensive in-depth knowledge of the nature of lupus skin lesions to guide the development of better treatments. |
| Organism | Homo sapiens |
| Data Type | Expression Profiling |
| Data Accessibility | Controlled-access |
| BioProject | PRJCA049473 |
| Release Date | 2026-04-22 |
| Submitter | Qianjin Lu (qianlu5860@pumcderm.cams.cn) |
| Organization | Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College |
| Submission Date | 2025-10-28 |
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| File ID | File Title | Number/Samples | File Type | File Size | File Suffix | Download |
|---|---|---|---|---|---|---|
| OMIX012568-01 | HC3_Cellbin | 1 | Expression Profiling | 74.17 MB | gem.gz | Controlled |
| OMIX012568-02 | DLE2_Cellbin | 1 | Expression Profiling | 162.24 MB | gem.gz | Controlled |
| OMIX012568-03 | HC4_Cellbin | 1 | Expression Profiling | 25.14 MB | gem.gz | Controlled |
| OMIX012568-04 | DLE5_Cellbin | 1 | Expression Profiling | 207.34 MB | gem.gz | Controlled |
| OMIX012568-05 | SLE1_Cellbin | 1 | Expression Profiling | 55.49 MB | gem.gz | Controlled |
| OMIX012568-06 | DLE4_Cellbin | 1 | Expression Profiling | 228.86 MB | gem.gz | Controlled |
| OMIX012568-07 | SLE5_Cellbin | 1 | Expression Profiling | 278.82 MB | gem.gz | Controlled |
| OMIX012568-08 | SLE3_Cellbin | 1 | Expression Profiling | 66.31 MB | gem.gz | Controlled |
| OMIX012568-09 | SLE6_Cellbin | 1 | Expression Profiling | 38.72 MB | gem.gz | Controlled |
| OMIX012568-10 | SLE2_Cellbin | 1 | Expression Profiling | 288.7 MB | gem.gz | Controlled |
| OMIX012568-11 | SLE4_Cellbin | 1 | Expression Profiling | 296.46 MB | gem.gz | Controlled |
| OMIX012568-12 | DLE3_Cellbin | 1 | Expression Profiling | 146.31 MB | gem.gz | Controlled |
| OMIX012568-13 | HC1_Cellbin | 1 | Expression Profiling | 79.06 MB | gem.gz | Controlled |
| OMIX012568-14 | HC2_Cellbin | 1 | Expression Profiling | 73.81 MB | gem.gz | Controlled |
| OMIX012568-15 | DLE1_Cellbin | 1 | Expression Profiling | 156.59 MB | gem.gz | Controlled |
| Paper Title | Journal Name | Publish Time | Accession | Citing Type |
|---|---|---|---|---|
| Spatial characterization of skin lesions in discoid and systemic lupus erythematosus | Nature Communications | 2026-05 | OMIX012568 | Deposit |