| Description |
We conducted a longitudinal study in which plasma samples from participants were collected during the first, second, and third trimesters of pregnancy for targeted metabolomics analysis. Our study aimed to explore the dynamic patterns of change and the overall effects of the trimethylamine N-oxide and its precursor metabolites (TMAOs) in the development of gestational diabetes mellitus (GDM) and to identify independent risk factors. We find early pregnancy L-carnitine elevation predicts GDM risk, while late pregnancy choline and trimethylamine shift to protective properties, emphasizing temporal precision in metabolic interventions, and suggesting stage-specific dietary strategies. These research outcomes offer a novel perspective for a more profound comprehension of the pathogenesis of GDM and establish a foundation for the creation of new diagnostic markers and therapeutic strategies centered on metabolite regulation. This project includes metabolomic data from 30 cases of GDM and 30 healthy samples. |