OMIX013458

1Summary

Title	Targeting de novo pyrimidine synthesis confers vulnerability to copper-mediated ATR inactivation in PARP inhibitor-resistant ovarian cancer
Description	Metabolite Extraction and Untargeted Profiling
Organism	Homo sapiens
Data Type	Metabolome Data by Mass Spectrometry (MS)
Data Accessibility	Open-access
BioProject	PRJCA052707
Release Date	2025-12-03
Submitter	Yabing Nan (nanyabing@tmu.edu.cn)
Organization	Cancer Hospital, Chinese Academy of Medical Sciences
Submission Date	2025-12-02

2Files & Download

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File ID	File Title	Number/Samples	File Type	File Size	File Suffix	Download
OMIX013458-01	EC-1_POS	1	Metabolome Data by Mass Spectrometry (MS)	172.84 MB	wiff.scan	FTP HTTPs
OMIX013458-02	Control-3_POS	1	Metabolome Data by Mass Spectrometry (MS)	173.7 MB	wiff.scan	FTP HTTPs
OMIX013458-03	Ola-1_POS	1	Metabolome Data by Mass Spectrometry (MS)	170.69 MB	wiff.scan	FTP HTTPs
OMIX013458-04	EC-Ola-6_POS	1	Metabolome Data by Mass Spectrometry (MS)	168.85 MB	wiff.scan	FTP HTTPs
OMIX013458-05	Control-2_POS	1	Metabolome Data by Mass Spectrometry (MS)	176.42 MB	wiff.scan	FTP HTTPs
OMIX013458-06	Control-5_POS	1	Metabolome Data by Mass Spectrometry (MS)	173.92 MB	wiff.scan	FTP HTTPs
OMIX013458-07	EC-3_POS	1	Metabolome Data by Mass Spectrometry (MS)	174.88 MB	wiff.scan	FTP HTTPs
OMIX013458-08	Ola-6_POS	1	Metabolome Data by Mass Spectrometry (MS)	171.21 MB	wiff.scan	FTP HTTPs
OMIX013458-09	EC-Ola-2_POS	1	Metabolome Data by Mass Spectrometry (MS)	170.28 MB	wiff.scan	FTP HTTPs
OMIX013458-10	EC-Ola-4_POS	1	Metabolome Data by Mass Spectrometry (MS)	168.75 MB	wiff.scan	FTP HTTPs
OMIX013458-11	Ola-3_POS	1	Metabolome Data by Mass Spectrometry (MS)	173.78 MB	wiff.scan	FTP HTTPs
OMIX013458-12	Control-1_POS	1	Metabolome Data by Mass Spectrometry (MS)	184.42 MB	wiff.scan	FTP HTTPs
OMIX013458-13	EC-4_POS	1	Metabolome Data by Mass Spectrometry (MS)	172.36 MB	wiff.scan	FTP HTTPs
OMIX013458-14	EC-Ola-1_POS	1	Metabolome Data by Mass Spectrometry (MS)	173.25 MB	wiff.scan	FTP HTTPs
OMIX013458-15	Ola-2_POS	1	Metabolome Data by Mass Spectrometry (MS)	169.46 MB	wiff.scan	FTP HTTPs
OMIX013458-16	EC-2_POS	1	Metabolome Data by Mass Spectrometry (MS)	181.97 MB	wiff.scan	FTP HTTPs
OMIX013458-17	Control-4_POS	1	Metabolome Data by Mass Spectrometry (MS)	181.27 MB	wiff.scan	FTP HTTPs
OMIX013458-18	EC-5_POS	1	Metabolome Data by Mass Spectrometry (MS)	173.35 MB	wiff.scan	FTP HTTPs
OMIX013458-19	Ola-4_POS	1	Metabolome Data by Mass Spectrometry (MS)	168.76 MB	wiff.scan	FTP HTTPs
OMIX013458-20	EC-Ola-3_POS	1	Metabolome Data by Mass Spectrometry (MS)	171.2 MB	wiff.scan	FTP HTTPs
OMIX013458-21	Control-6_POS	1	Metabolome Data by Mass Spectrometry (MS)	173.49 MB	wiff.scan	FTP HTTPs
OMIX013458-22	EC-Ola-5_POS	1	Metabolome Data by Mass Spectrometry (MS)	172.55 MB	wiff.scan	FTP HTTPs
OMIX013458-23	Ola-5_POS	1	Metabolome Data by Mass Spectrometry (MS)	166.92 MB	wiff.scan	FTP HTTPs
OMIX013458-24	EC-6_POS	1	Metabolome Data by Mass Spectrometry (MS)	174.2 MB	wiff.scan	FTP HTTPs
OMIX013458-25	Ola-6_NEG	1	Metabolome Data by Mass Spectrometry (MS)	63.67 MB	wiff.scan	FTP HTTPs
OMIX013458-26	EC-Ola-4_NEG	1	Metabolome Data by Mass Spectrometry (MS)	60.29 MB	wiff.scan	FTP HTTPs
OMIX013458-27	EC-4_NEG	1	Metabolome Data by Mass Spectrometry (MS)	70.48 MB	wiff.scan	FTP HTTPs
OMIX013458-28	EC-Ola-2_NEG	1	Metabolome Data by Mass Spectrometry (MS)	63.47 MB	wiff.scan	FTP HTTPs
OMIX013458-29	Ola-5_NEG	1	Metabolome Data by Mass Spectrometry (MS)	59.27 MB	wiff.scan	FTP HTTPs
OMIX013458-30	Ola-2_NEG	1	Metabolome Data by Mass Spectrometry (MS)	64.32 MB	wiff.scan	FTP HTTPs
OMIX013458-31	EC-Ola-3_NEG	1	Metabolome Data by Mass Spectrometry (MS)	68.86 MB	wiff.scan	FTP HTTPs
OMIX013458-32	Control-5_NEG	1	Metabolome Data by Mass Spectrometry (MS)	64.95 MB	wiff.scan	FTP HTTPs
OMIX013458-33	EC-Ola-6_NEG	1	Metabolome Data by Mass Spectrometry (MS)	60.4 MB	wiff.scan	FTP HTTPs
OMIX013458-34	Control-4_NEG	1	Metabolome Data by Mass Spectrometry (MS)	59.36 MB	wiff.scan	FTP HTTPs
OMIX013458-35	Control-3_NEG	1	Metabolome Data by Mass Spectrometry (MS)	65.6 MB	wiff.scan	FTP HTTPs
OMIX013458-36	EC-5_NEG	1	Metabolome Data by Mass Spectrometry (MS)	67.69 MB	wiff.scan	FTP HTTPs
OMIX013458-37	Ola-1_NEG	1	Metabolome Data by Mass Spectrometry (MS)	64.58 MB	wiff.scan	FTP HTTPs
OMIX013458-38	EC-2_NEG	1	Metabolome Data by Mass Spectrometry (MS)	66.54 MB	wiff.scan	FTP HTTPs
OMIX013458-39	EC-3_NEG	1	Metabolome Data by Mass Spectrometry (MS)	68.28 MB	wiff.scan	FTP HTTPs
OMIX013458-40	Control-2_NEG	1	Metabolome Data by Mass Spectrometry (MS)	57.84 MB	wiff.scan	FTP HTTPs
OMIX013458-41	EC-Ola-1_NEG	1	Metabolome Data by Mass Spectrometry (MS)	67.72 MB	wiff.scan	FTP HTTPs
OMIX013458-42	EC-1_NEG	1	Metabolome Data by Mass Spectrometry (MS)	71.34 MB	wiff.scan	FTP HTTPs
OMIX013458-43	Ola-3_NEG	1	Metabolome Data by Mass Spectrometry (MS)	64.59 MB	wiff.scan	FTP HTTPs
OMIX013458-44	EC-Ola-5_NEG	1	Metabolome Data by Mass Spectrometry (MS)	62.88 MB	wiff.scan	FTP HTTPs
OMIX013458-45	Ola-4_NEG	1	Metabolome Data by Mass Spectrometry (MS)	68.1 MB	wiff.scan	FTP HTTPs
OMIX013458-46	Control-6_NEG	1	Metabolome Data by Mass Spectrometry (MS)	60.73 MB	wiff.scan	FTP HTTPs
OMIX013458-47	EC-6_NEG	1	Metabolome Data by Mass Spectrometry (MS)	61.94 MB	wiff.scan	FTP HTTPs
OMIX013458-48	Control-1_NEG	1	Metabolome Data by Mass Spectrometry (MS)	59.27 MB	wiff.scan	FTP HTTPs

3Relevant Publications

Paper Title	Journal Name	Publish Time	Accession	Citing Type
Targeting de novo pyrimidine synthesis confers vulnerability to copper-mediated ATR inactivation in PARP inhibitor-resistant ovarian cancer	Nature Communications	2026-02	OMIX013458	Deposit

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