| Title |
Tescalcin is a phagocytic checkpoint driving immune escape and limiting immunotherapeutic efficacy in hepatocellular carcinoma |
| Description |
Immune checkpoint blockade targeting programmed cell death protein-1 (PD-1) has shown clinical benefit in advanced hepatocellular carcinoma (HCC). However, most patients exhibit limited responses to anti-PD-1 therapy. In a cohort of HCC patients treated with anti-PD-1 antibodies, we identified Tescalcin (TESC) as a previously unrecognized phagocytic checkpoint. Targeting TESC markedly enhances the engulfment of dying tumor cells by antigen-presenting cells, thereby promoting CD8+ T cell function and potentiating the therapeutic efficacy of anti-PD-1 antibodies. |
| Organism |
Mus musculus |
| Data Type |
Proteomic Data by Mass Spectrometry (MS) |
| Data Accessibility |
Open-access |
| BioProject |
PRJCA056780 |
| Release Date |
2026-03-23 |
| Submitter |
Zhongguo Zhou (zhouzhg@sysucc.org.cn) |
| Organization |
Sun Yat-sen University Cancer Center |
| Submission Date |
2026-01-29 |