| Title | Mechanism of FLI1 in promoting glioblastoma development |
|---|---|
| Description | Glioma is a common primary malignant brain tumor characterized by high malignancy and poor prognosis. Currently, there are no effective targeted therapies, making the identification of novel potential therapeutic targets an urgent priority. As a member of the ETS transcription factor family, FLI1 (Friend Leukemia Virus Integration 1) plays a pivotal role in the progression of various solid tumors. We observed that aberrant overexpression of FLI1 is closely associated with malignant phenotypes and poor prognosis in glioma. However, the specific role and underlying mechanisms of FLI1 in glioma progression remain unclear. This study investigates and validates the oncogenic role and mechanisms of FLI1 in glioma development. Using FLI1 Co-IP, we screened for and identified novel target molecules. Our experimental data demonstrate that FLI1 not only drives tumorigenesis through canonical oncogenic pathways but also regulates glioma progression across multiple levels. |
| Organism | Homo sapiens |
| Data Type | Proteomic Data by Mass Spectrometry (MS) |
| Data Accessibility | Open-access |
| BioProject | PRJCA063963 |
| Release Date | 2026-05-15 |
| Submitter | Jifan Hu (wenxuejdyy@jlu.edu.cn) |
| Organization | First Hospital of Jilin University |
| Submission Date | 2026-05-14 |
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| File ID | File Title | Number/Samples | File Type | File Size | File Suffix | Download |
|---|---|---|---|---|---|---|
| OMIX016920-01 | U87MG-IgG-CoIP | 1 | Proteomic Data by Mass Spectrometry (MS) | 531.22 MB | raw | |
| OMIX016920-02 | U251MG-FLI1-CoIP | 1 | Proteomic Data by Mass Spectrometry (MS) | 534.77 MB | raw | |
| OMIX016920-03 | U87MG-FLI1-CoIP | 1 | Proteomic Data by Mass Spectrometry (MS) | 515.2 MB | raw | |
| OMIX016920-04 | U251MG-IgG-CoIP | 1 | Proteomic Data by Mass Spectrometry (MS) | 490.27 MB | raw |
| Paper Title | Journal Name | Publish Time | Accession | Citing Type |
|---|---|---|---|---|
| FLI1 enhances the malignant phenotype of glioma cells and exerts immunomodulatory effects through feedback crosstalk with exonic circRNA FECR1 and interferon‑induced ISG15 | International Journal of Molecular Medicine | 2026-07 | OMIX016920 | Reference |