| Title | Single-nucleus RNA sequencing of mouse kidneys with podocyte injury induced by adriamycin and obesity |
|---|---|
| Description | Podocyte injury is a critical event in the development and progression of chronic kidney disease. To investigate the cellular and molecular alterations associated with podocyte injury, we established two mouse models of podocyte damage, including adriamycin-induced nephropathy and obesity-associated kidney injury. Kidney tissues were collected and subjected to single-nucleus RNA sequencing (snRNA-seq) using the 10x Genomics platform. |
| Organism | Mus musculus |
| Data Type | Expression Profiling |
| Data Accessibility | Open-access |
| BioProject | PRJCA066572 |
| Release Date | 2026-06-13 |
| Submitter | Junnan Wu (Junnan.wu@zju.edu.cn) |
| Organization | Sir Run Run Shaw Hospital, Zhejiang University School of Medicine |
| Submission Date | 2026-06-12 |
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| File ID | File Title | Number/Samples | File Type | File Size | File Suffix | Download |
|---|---|---|---|---|---|---|
| OMIX017659-01 | OB2 | 1 | Expression Profiling | 123.02 MB | tar.gz | |
| OMIX017659-02 | OB1 | 1 | Expression Profiling | 107.29 MB | tar.gz | |
| OMIX017659-03 | OB3 | 1 | Expression Profiling | 100.35 MB | tar.gz | |
| OMIX017659-04 | ADRN3 | 1 | Expression Profiling | 73.94 MB | tar.gz | |
| OMIX017659-05 | ADRN1 | 1 | Expression Profiling | 76.93 MB | tar.gz | |
| OMIX017659-06 | Con1 | 1 | Expression Profiling | 54.09 MB | tar.gz | |
| OMIX017659-07 | ADRN2 | 1 | Expression Profiling | 82.54 MB | tar.gz | |
| OMIX017659-08 | CTL1 | 1 | Expression Profiling | 66.34 MB | tar.gz | |
| OMIX017659-09 | Con2 | 1 | Expression Profiling | 50.65 MB | tar.gz | |
| OMIX017659-10 | CTL2 | 1 | Expression Profiling | 76.24 MB | tar.gz | |
| OMIX017659-11 | CTL3 | 1 | Expression Profiling | 54.16 MB | tar.gz | |
| OMIX017659-12 | Con3 | 1 | Expression Profiling | 53.31 MB | tar.gz |
| Paper Title | Journal Name | Publish Time | Accession | Citing Type |
|---|---|---|---|---|
| Epigallocatechin-3-gallate attenuates oxidative stress and apoptosis in podocytes of focal segmental glomerulosclerosis | Renal Failure | 2026-08 | OMIX017659 OMIX017749 | Deposit |
| Single-cell and high-resolution spatial profiling of podocytopathies reveals core mechanisms of podocyte injury | Science Advances | 2026-07 | OMIX017659 OMIX017749 | Deposit |