Proteomic profiling of dog brains after social isolation
| Title | Proteomic profiling of dog brains after social isolation |
|---|---|
| Description | Using Tandem mass spectrometry (TMT)-labeled quantitative proteomics, we established a comprehensive proteome database of canines' brain by comparing protein expression levels in three age groups (newborns, 3 months and adults) in six brain regions (hippocampus, cerebellum, prefrontal cortex, olfactory bulb and striatum). We found a more substantial difference in proteome between newborn and 3-month puppy brain than that between 3-month and adult brain. We report that dogs isolated for 4 weeks 62 days after birth showed increased functional connectivity by functional MRI and decreased myelination in the prefrontal cortex by RNA seq and proteome analysis together with immunochemical analysis. These findings provide an omics and neural connectivity context to understand the consequences of SI and offer novel targets to develop therapies against SI-induced brain damage. |
| Organism | Canis lupus familiaris |
| Data Type | - |
| Data Accessibility | Open-access |
| BioProject | PRJCA004289 |
| Release Date | 2021-06-30 |
| Submitter | Yong Zhang (yqzhang@genetics.ac.cn) |
| Organization | Institute of Genetics and Developmental Biology, Chinese Academy of Sciences |
| Submission Date | 2021-01-19 |
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| File ID | File Title | Number/Samples | File Type | File Size | File Suffix | Download Times | Download |
|---|---|---|---|---|---|---|---|
| OMIX231-10-01 | Social Isolation affects the proteome of brain | 1 | Proteomic | 20.8 GB | rar | 8 |