OMIX

Proteomic profiling of dog brains after social isolation

OMIX231

1Summary
Title Proteomic profiling of dog brains after social isolation
Description Using Tandem mass spectrometry (TMT)-labeled quantitative proteomics, we established a comprehensive proteome database of canines' brain by comparing protein expression levels in three age groups (newborns, 3 months and adults) in six brain regions (hippocampus, cerebellum, prefrontal cortex, olfactory bulb and striatum). We found a more substantial difference in proteome between newborn and 3-month puppy brain than that between 3-month and adult brain. We report that dogs isolated for 4 weeks 62 days after birth showed increased functional connectivity by functional MRI and decreased myelination in the prefrontal cortex by RNA seq and proteome analysis together with immunochemical analysis. These findings provide an omics and neural connectivity context to understand the consequences of SI and offer novel targets to develop therapies against SI-induced brain damage.
Organism Canis lupus familiaris
Data Type -
Data Accessibility Open-access
BioProject PRJCA004289
Release Date 2021-06-30
Submitter Yong Zhang (yqzhang@genetics.ac.cn)
Organization Institute of Genetics and Developmental Biology, Chinese Academy of Sciences
Submission Date 2021-01-19
2Files & Download

HTTP download speed may be slow. It is highly recommended that you download the dataset using a dedicated FTP tool (such as FileZilla Client).

File ID File Title Number/Samples File Type File Size File Suffix Download Times Download
OMIX231-10-01 Social Isolation affects the proteome of brain 1 Proteomic 20.8 GB rar 8

View All Released Data of OMIX