OMIX236

1Summary
Title Sequential progenitor states mark the generation of pancreatic endocrine lineages in mice and humans
Description To investigate endocrine lineage differentiation pathways in humans, we performed scRNA-seq of pancreatic cells from human embryos at 9-19 weeks post conception (W) using a modified STRT-seq (mSTRT-seq) method. We also performed 10x Genomics scRNA-seq of whole human pancreatic cells at W8-19, and enriched multipotent pancreatic progenitor and acinar cells (EpCAM+GP2+) and endocrine cells (EpCAM+GP2-) at W12.
Organism Homo sapiens
Data Type Mixed
Data Accessibility Open-access
BioProject PRJCA004336
Release Date 2021-04-27
Submitter Cheng-Ran Xu (cxu@pku.edu.cn)
Organization Peking University
Submission Date 2021-02-05
2Files & Download

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File ID File Title Number/Samples File Type File Size File Suffix Download
OMIX236-20-01 Human_mSTRTSeq.UMI.txt.gz 21 Transcriptomic 24.7 MB gz
OMIX236-20-02 Human_10x.UMI.txt.gz 9 Transcriptomic 91.5 MB gz
OMIX236-99-03 OMIX_gene_expression_profile.xlsx 0 others 26.5 KB xlsx
3Relevant Publications
Paper Title Journal Name Publish Time Accession Citing Type
Long-term in vitro expansion of a human fetal pancreas stem cell that generates all three pancreatic cell lineages Cell 2024-12 OMIX236 Secondary use
Single-cell transcriptomic and spatial landscapes of the developing human pancreas Cell Metabolism 2023-01 OMIX236 Secondary use
Understanding cell fate acquisition in stem-cell-derived pancreatic islets using single-cell multiome-inferred regulomes Developmental Cell 2023-05 OMIX236 Secondary use
A transcriptional cross species map of pancreatic islet cells Molecular Metabolism 2022-12 OMIX236 Secondary use
Sequential progenitor states mark the generation of pancreatic endocrine lineages in mice and humans Cell Research 2021-08 OMIX236 Deposit
USP7 controls NGN3 stability and pancreatic endocrine lineage development Nature Communications 2023-04 OMIX236 Secondary use
Deciphering early human pancreas development at the single-cell level Nature Communications 2023-09 OMIX001616 OMIX236 Deposit
Secondary use
A multimodal cross-species comparison of pancreas development Nature Communications 2025-10 OMIX236 Secondary use
A multimodal cross-species comparison of pancreas development Research Square 2024-04 OMIX236 Secondary use

View All Released Data of OMIX