Discover a new hRPA-activated BLM unwinding mode.
| Title | Discover a new hRPA-activated BLM unwinding mode. |
|---|---|
| Description | BLM is a multifunctional helicase that plays critical roles in maintaining genome stability. Using a combined single-molecule approach, we found that human replication protein A (hRPA) not only ensures that limited quantities of BLMs processively unwind nicked dsDNA but also permits the translocation of BLMs on both intact and nicked ssDNAs, resulting in a bidirectional unwinding mode. Our findings present novel DNA unwinding activities of BLM that potentially facilitate its function switching in DNA repair. |
| Organism | Gallus gallus |
| Data Type | - |
| Data Accessibility | Open-access |
| BioProject | PRJCA006631 |
| Release Date | 2021-09-19 |
| Submitter | Xia Zhang (zhangxia@shanghaitech.edu.cn) |
| Organization | ShanghaiTech University |
| Submission Date | 2021-09-19 |
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| File ID | File Title | Number/Samples | File Type | File Size | File Suffix | Download Times | Download |
|---|---|---|---|---|---|---|---|
| OMIX657-10-01 | Discover a new hRPA-activated BLM unwinding mode. | 20511 | Proteomic | 10.73 GB | rar | 0 |