Interference PTPRZ1 expression profiling chip in glioma stem cells
| Title | Interference PTPRZ1 expression profiling chip in glioma stem cells |
|---|---|
| Description | We report that TAM secretes abundant pleiotropic protein (PTN) to stimulate glioma stem cells (GSC) through its receptor PTPRZ1, thereby promoting the malignant growth of GBM through PTN-PTPRZ1 paracrine signaling. The expression of PTN is correlated with the infiltration of CD11b+/CD163+ TAM and the poor prognosis of GBM patients. Co-implantation of M2-like macrophages (MLC) promotes GSC-driven tumor growth, but silencing PTN expression in MLC reduces their pro-tumorigenic activity. The PTN receptor PTPRZ1 is preferentially expressed in GSC and also predicts poor prognosis for GBM. Destruction of PTPRZ1 abolished the maintenance and tumorigenic potential of GSC. |
| Organism | Mus |
| Data Type | - |
| Data Accessibility | Open-access |
| BioProject | PRJCA005262 |
| Release Date | 2021-09-24 |
| Submitter | Xiuwu Bian (bianxiuwuoffice@163.com) |
| Organization | military |
| Submission Date | 2021-09-23 |
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| File ID | File Title | Number/Samples | File Type | File Size | File Suffix | Download Times | Download |
|---|---|---|---|---|---|---|---|
| OMIX663-06-01 | Interference PTPRZ1 expression profiling chip in glioma stem cells | 1 | Genotype | 12.7 MB | rar | 0 |