Plasma metagenomic next-generation sequencing of microbial cell-free DNA detects pathogens in patients with suspected infected pancreatic necrosis
| Title | Plasma metagenomic next-generation sequencing of microbial cell-free DNA detects pathogens in patients with suspected infected pancreatic necrosis |
|---|---|
| Description | From October 2020 to October 2021, forty-four suspected infected pancreatic necrosis (IPN) patients who underwent plasma mNGS were reviewed. The study subjects were deemed confirmed IPN or sterile pancreatic necrosis based on microbiological findings within two weeks after the index sampling. The distribution of the pathogens identified by plasma mNGS was analyzed. Positive percent agreement (PPA) and negative percent agreement (NPA) were evaluated based on the conformity between the overall mNGS results and culture results of IPN drains. In addition, the clinical outcomes were compared between mNGS positive and negative patients. |
| Organism | Human betaherpesvirus 5 |
| Data Type | - |
| Data Accessibility | Open-access |
| BioProject | PRJCA008208 |
| Release Date | 2022-04-10 |
| Submitter | Ye Zhang (zhangye@hugobiotech.com) |
| Organization | Hugobiotech Beijing Co.,Ltd. |
| Submission Date | 2022-02-10 |
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| File ID | File Title | Number/Samples | File Type | File Size | File Suffix | Download Times | Download |
|---|---|---|---|---|---|---|---|
| OMIX930-04-01 | Plasma metagenomic next-generation sequencing | 95 | Genome-Wide Association Study (GWAS) | 378.2 KB | zip | 0 |