Metagenomic Next-Generation Sequencing versus Traditional Pathogen Detection in the Diagnosis of Infection after Allogeneic Hematopoietic Stem Cell Transplantation in Children
| Title | Metagenomic Next-Generation Sequencing versus Traditional Pathogen Detection in the Diagnosis of Infection after Allogeneic Hematopoietic Stem Cell Transplantation in Children |
|---|---|
| Description | We compared metagenomic next-generation sequencing (mNGS) and traditional pathogen detection in investigating the pathogens of infections (such as bloodstream infections, pulmonary infections, and central nervous system (CNS) infections) in pediatric allo-HSCT recipients. This study retrospectively analyzed 101 pediatric recipients of allo-HSCT, including 54 bronchoalveolar lavage fluid samples, 32 blood samples, and 15 cerebrospinal fluid samples. Eighty-seven were diagnosed with post-transplant infectious diseases and 14 with non-infectious diseases eventually. The sensitivity and specificity of mNGS were compared to traditional pathogen detection methods. |
| Organism | human metagenome |
| Data Type | - |
| Data Accessibility | Open-access |
| BioProject | PRJCA008385 |
| Release Date | 2022-04-25 |
| Submitter | Ye Zhang (zhangye@hugobiotech.com) |
| Organization | Hugobiotech Beijing Co.,Ltd. |
| Submission Date | 2022-02-25 |
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| File ID | File Title | Number/Samples | File Type | File Size | File Suffix | Download Times | Download |
|---|---|---|---|---|---|---|---|
| OMIX974-04-01 | mNGS_Reads_1 | 158 | Genome-Wide Association Study (GWAS) | 27.0 MB | zip | 0 |