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Innovation (Cambridge (Mass.))
May 28, 2021;2 (2): 100099.

Phylogenomic tracing of asymptomatic transmission in a COVID-19 outbreak.

Ju Zhang, Nan Ding, Yangzi Song, Rui Song, Yang Pan, Linghang Wang, Shuo Yan, Qi Wang, Shanfang Ma, Lirong Wei, Fengting Yu, Lianhe Lu, Fujie Zhang, Chen Chen, Hui Zeng
Author Information
  1. Ju Zhang: Beijing Ditan Hospital, Capital Medical University, Beijing 100015, China.
  2. Nan Ding: Beijing Ditan Hospital, Capital Medical University, Beijing 100015, China.
  3. Yangzi Song: Beijing Ditan Hospital, Capital Medical University, Beijing 100015, China.
  4. Rui Song: Beijing Ditan Hospital, Capital Medical University, Beijing 100015, China.
  5. Yang Pan: Institute for Infectious Disease and Endemic Disease Control, Beijing Center for Disease Prevention and Control, Beijing 100013, China.
  6. Linghang Wang: Beijing Ditan Hospital, Capital Medical University, Beijing 100015, China.
  7. Shuo Yan: Beijing Ditan Hospital, Capital Medical University, Beijing 100015, China.
  8. Qi Wang: Beijing Ditan Hospital, Capital Medical University, Beijing 100015, China.
  9. Shanfang Ma: Beijing Ditan Hospital, Capital Medical University, Beijing 100015, China.
  10. Lirong Wei: Beijing Ditan Hospital, Capital Medical University, Beijing 100015, China.
  11. Fengting Yu: Beijing Ditan Hospital, Capital Medical University, Beijing 100015, China.
  12. Lianhe Lu: Beijing Ditan Hospital, Capital Medical University, Beijing 100015, China.
  13. Fujie Zhang: Beijing Ditan Hospital, Capital Medical University, Beijing 100015, China.
  14. Chen Chen: Beijing Ditan Hospital, Capital Medical University, Beijing 100015, China.
  15. Hui Zeng: Beijing Ditan Hospital, Capital Medical University, Beijing 100015, China.
PMID: 33778799 DOI: 10.1016/j.xinn.2021.100099

Abstract

SARS-CoV-2 has caused over 100 million deaths and continues to spread rapidly around the world. Asymptomatic transmission of SARS-CoV-2 is the Achilles' heel of COVID-19 public health control measures. Phylogenomic data on SARS-CoV-2 could provide more direct information about asymptomatic transmission. In this study, using a novel MINERVA sequencing technology, we traced asymptomatic transmission of COVID-19 patients in Beijing, China. One hundred and seventy-eight close contacts were quarantined, and 14 COVID-19 patients were laboratory confirmed by RT-PCR. We provide direct phylogenomic evidence of asymptomatic transmission by constructing the median joining network in the cluster. These data could help us to determine whether the current symptom-based screening should cover asymptomatic persons.

Keywords

COVID-19 SARS-CoV-2 asymptomatic transmission outbreak phylogenomic

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