Os05g0597100

The rice Os05g0597100 was reported as HDT701 in 2012 by researchers from USA and China.

Annotated Information

Gene Symbol

• Os05g0597100 <=> HDT701,OsHDT1

Function

• HDT701 is a member of the plant-specific HD2 subfamily of HDACsencodes which a Histone H4 Deacetylase.
• HDT701 negatively regulates innate immunity by modulating the levels of histone H4 acetylation of PRR and defense-related genes in rice.

Expression

• Transcription of HDT701 is increased in the compatible reaction and decreased in the incompatible reaction after infection by the fungal pathogen Magnaporthe oryzae.
• HDT701 can bind to defense-related genes to regulate their expression.

Evolution

• Overexpression of HDT701 in transgenic rice leads to decreased levels of histone H4 acetylation and enhanced susceptibility to the rice pathogens M. oryzae and Xanthomonas oryzae pv oryzae (Xoo).
• By contrast, silencing of HDT701 in transgenic rice causes elevated levels of histone H4 acetylation and elevated transcription of pattern recognition receptor (PRR) and defense-related genes, increased generation of reactive oxygen species after pathogen-associated molecular pattern elicitor treatment, as well as enhanced resistance to both M. oryzae and Xoo.

Labs working on this gene

• Department of Plant Pathology, Ohio State University, Columbus, Ohio 43210
• State Laboratory for Biology of Plant Diseases and Insect Pests, Institute of Plant Protection, Chinese Academy of Agricultural Sciences, Beijing 100193, China
• Department of Plant and Soil Sciences, Delaware Biotechnology Institute, University of Delaware, Newark, Delaware 19711