Os07g0184900
The rice gene Os07g0184900 was reported as OsKu70 in 2010[1] by researchers from Korea.
Contents
Annotated Information
Gene Symbol
- Os07g0184900 <=> OsKu70, Ku70
Function
- The cellular functions of Ku70 in repair of DNA double-stranded breaks and telomere regulation have been described in a wide range of organisms. OsKu70 is a homolog of Ku70 in rice genome.
- OsKu70 physically interacts with OsKu80.
- OsKu70 is required for the maintenance of chromosome stability and normal developmental growth in rice plants.
Mutation
- The homozygous G2 osku70 mutant lines were more sensitive than wild-type plants to a DNA-damaging agent (0.01%–0.05% methyl-methane sulfonate), consistent with the notion that OsKu70 participates in the DNA repair mechanism. Terminal restriction fragment analysis revealed that telomeres in homozygous G2 osku70 mutants were markedly longer (10–20 kb) than those in wild-type plants (5–10 kb), whereas telomere length in heterozygous G2 osku70 mutant and T2 OsKu70-overexpressing transgenic (35S: OsKu70) rice resembled that of the wild-type plant. In contrast to what was observed in Arabidopsis (Arabidopsis thaliana) atku70 mutants, homozygous G2 osku70 rice plants displayed severe developmental defects in both vegetative and reproductive organs under normal growth conditions, resulting in sterile flowers. Analysis of meiotic progression in pollen mother cells demonstrated that up to 11.1% (seven of 63) of G2 mutant anaphase cells displayed one or more chromosomal fusions.
Expression
- OsKu70 transcript was detected constitutively in every tissue and developmental stage examined and also in
undifferentiated callus cells in rice.
Evolution
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Labs working on this gene
- Department of Biology, College of Life Science and Biotechnology, Yonsei University, Seoul 120–749, Korea (J.-P.H., M.Y.B., W.T.K.);
- Department of Life Science, Pohang University of Science and Technology, Pohang 790–784, Korea (K.A., G.A.);
- Genetics and Breeding Division, National Institute of Crop Science, Rural Development Administration, Suwon 441–857, Korea (S.-J.Y.)
References
- ↑ Hong JP, Byun MY, An K, Yang SJ, An G, Kim WT. OsKu70 is associated with developmental growth and genome stability in rice. Plant Physiol. 2010 Jan;152(1):374-87. doi: 10.1104/pp.109.150391. PubMed PMID: 19923234; PubMed Central PMCID: PMC2799371.
