Os07g0508500

The rice Os07g0508500 was reported as BRK1 in 2012 by researchers from China.

Annotated Information

Figure 2. Meiotic Chromosome Behavior in the Wild Type and brk1-1 Mutant..

Gene Symbol

• Os07g0508500 <=> BRK1,OsBRK1

Function

• BRK1 may be required for normal localization of Aurora kinase before the onset of metaphase I, which is responsible for correcting the merotelic attachment.
• BRK1 Is Essential for the Centromeric Localization of SGO1
• BRK1 Is Required for Phosphorylation of Rice H2A-T134 during Both Meiosis and Mitosis
• Depletion of BRK1 Reduces the Tension across Homologous Kinetochores during Metaphase I
• BRK1 Is Required for Correcting the Merotelic Attachment of Paired Sister Kinetochores during Metaphase I

Expression

• During prophase I, chromosomal behavior in brk1-1 was quite similar to the wild type (Figures 2A and 2E). Whereas at the onset of anaphase I in brk1-1, although homologous chromosomes could separate equally, the two sister chromatids of each chromosome started to disassociate from each other (Figure 2F).
• During telophase I in brk1-1, the sister chromatids of most chromosomes completely separated, and this precocious dissociation resulted in scattered chromatids that failed to line up on the equatorial plate during metaphase II (Figure 2G).
• Consequently, sister chromatids were unequally separated at anaphase II in brk1-1, and the lagging chromosomes finally led to the formation of micronuclei during the tetrad stage (Figure 2H).

Evolution

• BRK1 Localizes to Kinetochores during Both Meiosis and Mitosis

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Labs working on this gene

• State Key Laboratory of Plant Genomics and Center for Plant Gene Research, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China
• College of Plant Protection,Yunnan Agricultural University, Kunming 650201, China