Os12g0572800

The rice gene Os12g0572800 was reported as MEL2 in 2011 by researchers from Japan.

Annotated Information

Gene Symbol

• Os12g0572800 <=> MEL2, OSMEL2

Function

• In other eukaryotes, RNA-recognition-motif (RRM) proteins are known to play essential roles in germ-cell development and meiosis progression. Rice MEL2 gene encodes MEL2 protein which shows partial similarity with human proline-rich RRM protein, deleted in Azoospermia-Associated Protein1 (DAZAP1), though MEL2 also possesses ankyrin repeats and a RING finger motif.

• MEL2 is required for regulating the premeiotic G1/S-phase transition of male and female germ cells and also establishing synchrony of male meiosis.

Mutation

• Expression analyses of several cell-cycle markers revealed that, in mel2 mutant anthers, most germ cells failed to enter premeiotic S-phase and meiosis, and a part escaped from the defect and underwent meiosis with a significant delay or continued mitotic cycles.

Sublocalization

• Immunofluorescent detection revealed that T7 peptide-tagged MEL2 localized at cytoplasmic perinuclear region of germ cells during premeiotic interphase in transgenic rice plants.

Evolution

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Labs working on this gene

• Experimental Farm, National Institute of Genetics, Mishima, Shizuoka, Japan,
• Department of Life Science, Graduate University for Advanced Studies (SOKENDAI), Mishima, Shizuoka, Japan, 3 Laboratory for DNA Data Analysis, National Institute of Genetics, Mishima, Shizuoka, Japan,
• Division of Genome and Biodiversity Research, National Institute of Agrobiological Sciences, Tsukuba, Ibaraki, Japan,
• Plant Genetics Laboratory, National Institute of Genetics, Mishima, Shizuoka, Japan