Os12g0622500

From RiceWiki
Jump to: navigation, search

The rice Os12g0622500 was reported as OsSpo11-4 in 2011 [1] by researchers from the China.

Annotated Information

Gene Symbol

  • Os12g0622500 <=> OsSpo11-4

Function

  • Spo11 is essential for initiating meiotic recombination and this function appears conserved among other eukaryotes.

Mutant

  • OsSpo11-4 exhibited double-strand DNA cleavage activity and its enzymatic activity appears dependent on Mg2+ and independent of OsTopVIB, despite its interaction with OsTopVIB. We further analyzed the biological function of OsSpo11-4 by RNA interference and found that down-regulated expression of OsSpo11-4 led to defects in male meiosis, indicating OsSpo11-4 is required for meiosis.

Labs working on this gene

  • Chinese Ministry of Science and Technology
  • Natural Science Fundation of China

References

  1. ↑ OsSpo11-4, a Rice Homologue of the Archaeal TopVIA Protein, Mediates Double-Strand DNA Cleavage and Interacts with OsTopVIB


Structured Information

Retrieved from "https://ngdc.cncb.ac.cn/ricewiki/index.php?title=Os12g0622500&oldid=276475"