Difference between revisions of "Os07g0508500"
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| − | + | The rice '''''Os07g0508500''''' was reported as '''''BRK1''''' in 2012 <ref name="ref1" /> by researchers from China. | |
==Annotated Information== | ==Annotated Information== | ||
| + | [[File:108-Os07g0508500.png|right|thumb|327px|'''Figure 2.''' ''Meiotic Chromosome Behavior in the Wild Type and brk1-1 Mutant.<ref name="ref1" />.'']] | ||
| + | ===Gene Symbol=== | ||
| + | *'''''Os07g0508500''''' '''''<=>''''' '''''BRK1,OsBRK1''''' | ||
===Function=== | ===Function=== | ||
| − | + | * '''''BRK1''''' may be required for normal localization of Aurora kinase before the onset of metaphase I, which is responsible for correcting the merotelic attachment. | |
| − | + | * '''''BRK1''''' Is Essential for the Centromeric Localization of SGO1 | |
| + | * '''''BRK1''''' Is Required for Phosphorylation of Rice H2A-T134 during Both Meiosis and Mitosis | ||
| + | * Depletion of '''''BRK1''''' Reduces the Tension across Homologous Kinetochores during Metaphase I | ||
| + | * '''''BRK1''''' Is Required for Correcting the Merotelic Attachment of Paired Sister Kinetochores during Metaphase I | ||
===Expression=== | ===Expression=== | ||
| − | + | * During prophase I, chromosomal behavior in brk1-1 was quite similar to the wild type (Figures 2A and 2E). Whereas at the onset of anaphase I in brk1-1, although homologous chromosomes could separate equally, the two sister chromatids of each chromosome started to disassociate from each other (Figure 2F). | |
| + | * During telophase I in brk1-1, the sister chromatids of most chromosomes completely separated, and this precocious dissociation resulted in scattered chromatids that failed to line up on the equatorial plate during metaphase II (Figure 2G). | ||
| + | * Consequently, sister chromatids were unequally separated at anaphase II in brk1-1, and the lagging chromosomes finally led to the formation of micronuclei during the tetrad stage (Figure 2H). | ||
===Evolution=== | ===Evolution=== | ||
| − | + | * BRK1 Localizes to Kinetochores during Both Meiosis and Mitosis | |
You can also add sub-section(s) at will. | You can also add sub-section(s) at will. | ||
==Labs working on this gene== | ==Labs working on this gene== | ||
| − | + | * State Key Laboratory of Plant Genomics and Center for Plant Gene Research, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China | |
| − | + | * College of Plant Protection,Yunnan Agricultural University, Kunming 650201, China | |
==References== | ==References== | ||
| − | <ref name="ref1">BRK1, a Bub1- | + | <references> |
| + | * <ref name="ref1"> | ||
| + | Wang M, Tang D, Luo Q, Jin Y, Shen Y, Wang K, Cheng Z. BRK1, a Bub1-related | ||
| + | kinase, is essential for generating proper tension between homologous | ||
| + | kinetochores at metaphase I of rice meiosis. Plant Cell. 2012 Dec;24(12):4961-73. | ||
| + | doi: 10.1105/tpc.112.105874. Epub 2012 Dec 14. PubMed PMID: 23243128; PubMed | ||
| + | Central PMCID: PMC3556969. | ||
| + | </ref> | ||
| + | </references> | ||
==Structured Information== | ==Structured Information== | ||
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Latest revision as of 15:50, 17 October 2016
The rice Os07g0508500 was reported as BRK1 in 2012 [1] by researchers from China.
Contents
Annotated Information
Figure 2. Meiotic Chromosome Behavior in the Wild Type and brk1-1 Mutant.[1].
Gene Symbol
- Os07g0508500 <=> BRK1,OsBRK1
Function
- BRK1 may be required for normal localization of Aurora kinase before the onset of metaphase I, which is responsible for correcting the merotelic attachment.
- BRK1 Is Essential for the Centromeric Localization of SGO1
- BRK1 Is Required for Phosphorylation of Rice H2A-T134 during Both Meiosis and Mitosis
- Depletion of BRK1 Reduces the Tension across Homologous Kinetochores during Metaphase I
- BRK1 Is Required for Correcting the Merotelic Attachment of Paired Sister Kinetochores during Metaphase I
Expression
- During prophase I, chromosomal behavior in brk1-1 was quite similar to the wild type (Figures 2A and 2E). Whereas at the onset of anaphase I in brk1-1, although homologous chromosomes could separate equally, the two sister chromatids of each chromosome started to disassociate from each other (Figure 2F).
- During telophase I in brk1-1, the sister chromatids of most chromosomes completely separated, and this precocious dissociation resulted in scattered chromatids that failed to line up on the equatorial plate during metaphase II (Figure 2G).
- Consequently, sister chromatids were unequally separated at anaphase II in brk1-1, and the lagging chromosomes finally led to the formation of micronuclei during the tetrad stage (Figure 2H).
Evolution
- BRK1 Localizes to Kinetochores during Both Meiosis and Mitosis
You can also add sub-section(s) at will.
Labs working on this gene
- State Key Laboratory of Plant Genomics and Center for Plant Gene Research, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China
- College of Plant Protection,Yunnan Agricultural University, Kunming 650201, China
References
- ↑ 1.0 1.1 Wang M, Tang D, Luo Q, Jin Y, Shen Y, Wang K, Cheng Z. BRK1, a Bub1-related kinase, is essential for generating proper tension between homologous kinetochores at metaphase I of rice meiosis. Plant Cell. 2012 Dec;24(12):4961-73. doi: 10.1105/tpc.112.105874. Epub 2012 Dec 14. PubMed PMID: 23243128; PubMed Central PMCID: PMC3556969.
