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| − | Please input one-sentence summary here.
| + | The rice gene Os07g0184900 was reported as '''''OsKu70''''' in 2010<ref name="ref1" /> by researchers from Korea. |
| | | | |
| | ==Annotated Information== | | ==Annotated Information== |
| | + | ===Gene Symbol=== |
| | + | *'''''Os07g0184900 <=> OsKu70, Ku70 |
| | + | |
| | ===Function=== | | ===Function=== |
| − | Please input function information here.
| + | * The cellular functions of '''''Ku70''''' in repair of DNA double-stranded breaks and telomere regulation have been described in a wide range of organisms. '''''OsKu70''''' is a homolog of '''''Ku70''''' in rice genome. |
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| | + | * OsKu70 physically interacts with OsKu80. |
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| − | ===Expression=== | + | * '''''OsKu70''''' is required for the maintenance of chromosome stability and normal developmental growth in rice plants. |
| − | Please input expression information here.
| + | ===Mutation=== |
| | + | * The homozygous G2 osku70 mutant lines were more sensitive than wild-type plants to a DNA-damaging agent (0.01%–0.05% methyl-methane sulfonate), consistent with the notion that OsKu70 participates in the DNA repair mechanism. Terminal restriction fragment analysis revealed that telomeres in homozygous G2 osku70 mutants were markedly longer (10–20 kb) than those in wild-type plants (5–10 kb), whereas telomere length in heterozygous G2 osku70 mutant and T2 OsKu70-overexpressing transgenic (35S: OsKu70) rice resembled that of the wild-type plant. In contrast to what was observed in Arabidopsis (Arabidopsis thaliana) atku70 mutants, homozygous G2 osku70 rice plants displayed severe developmental defects in both vegetative and reproductive organs under normal growth conditions, resulting in sterile flowers. Analysis of meiotic progression in pollen mother cells demonstrated that up to 11.1% (seven of 63) of G2 mutant anaphase cells displayed one or more chromosomal fusions. |
| | + | ===Expression === |
| | + | * '''''OsKu70''''' transcript was detected constitutively in every tissue and developmental stage examined and also in |
| | + | undifferentiated callus cells in rice. |
| | | | |
| | ===Evolution=== | | ===Evolution=== |
| − | Please input evolution information here.
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| | You can also add sub-section(s) at will. | | You can also add sub-section(s) at will. |
| | + | ==Labs working on this gene== |
| | + | * Department of Biology, College of Life Science and Biotechnology, Yonsei University, Seoul 120–749, Korea (J.-P.H., M.Y.B., W.T.K.); |
| | + | * Department of Life Science, Pohang University of Science and Technology, Pohang 790–784, Korea (K.A., G.A.); |
| | + | * Genetics and Breeding Division, National Institute of Crop Science, Rural Development Administration, Suwon 441–857, Korea (S.-J.Y.) |
| | + | ==References== |
| | + | <references> |
| | + | * <ref name="ref1"> |
| | + | Hong JP, Byun MY, An K, Yang SJ, An G, Kim WT. OsKu70 is associated with |
| | + | developmental growth and genome stability in rice. Plant Physiol. 2010 |
| | + | Jan;152(1):374-87. doi: 10.1104/pp.109.150391. PubMed PMID: 19923234; PubMed |
| | + | Central PMCID: PMC2799371. |
| | | | |
| − | ==Labs working on this gene==
| + | </ref> |
| − | Please input related labs here.
| + | </references> |
| | | | |
| − | ==References==
| |
| − | Please input cited references here.
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| | | | |
| | ==Structured Information== | | ==Structured Information== |
| − | {{JaponicaGene|
| + | [[Category:Genes]][[Category:Oryza Sativa Japonica Group]][[Category:Japonica Chromosome 7]] |
| − | GeneName = Os07g0184900|
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| − | Description = Similar to Ku70-like protein|
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| − | Version = NM_001065596.1 GI:115470924 GeneID:4342584|
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| − | Length = 10993 bp|
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| − | Definition = Oryza sativa Japonica Group Os07g0184900, complete gene.|
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| − | Source = Oryza sativa Japonica Group
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| − | | |
| − | ORGANISM Oryza sativa Japonica Group
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| − | Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
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| − | Spermatophyta; Magnoliophyta; Liliopsida; Poales; Poaceae; BEP
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| − | clade; Ehrhartoideae; Oryzeae; Oryza.
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| − | |
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| − | Chromosome = [[:category:Japonica Chromosome 7|Chromosome 7]]|
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| − | AP = Chromosome 7:4517409..4528401|
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| − | CDS = 4517467..4517529,4517627..4517701,4517914..4518030,4518533..4518647,4519328..4519433<br>,4519684..4519801,4519905..4519988,4520059..4520117,4520697..4520830<br>,4520932..4520975,4521100..4521176,4521415..4521562,4522155..4522216<br>,4525701..4525761,4526212..4526304,4526372..4526489,4527003..4527105<br>,4527342..4527525,4527974..4528087|
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| − | GCID = <gbrowseImage1>
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| − | name=NC_008400:4517409..4528401
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| − | source=RiceChromosome07
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| − | preset=GeneLocation
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| − | </gbrowseImage1>|
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| − | GSID = <gbrowseImage2>
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| − | name=NC_008400:4517409..4528401
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| − | source=RiceChromosome07
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| − | preset=GeneLocation
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| − | </gbrowseImage2>|
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| − | CDNA = <cdnaseq>atggatctggaccccgagggcctcttccgcgacgacagcgacgaggatgacgacaacgtccaggagagggaggccaacaaggagatggtcgtctacctcatcgacgcctcgcccaagatgttcacccctgcgaccaaggcagatgaaaaggaggagacacattttcatacgatagtgaactgcatcacacatgcgctgaagacgcagattatcggtagatcctatgatgaagtcgctatatgtttctttaacacgaaagaaaagaagaatttacaggaattggctggtgtttatgtttataatgttacagagagagaaccacttgataggcctgatgcaagattgattaaggaattttcttgtatagaagattcttttatgagtaatattggaagtcggtacggaataacttctggatctcgagagaataccttgtacaatgctctttgggttgcacaggcattgctgcgtaaaggatctgtgaagactgtgagtaagcggattgttatattcaccaacgaagatgatccttttggtggtcttacaggagcagtaaagactgatatgataaggacaacaatccaacgtgcaagagatgcacaagatcttggcctgtccattgaacttcttcctttgagtaggcccgatgaggagttcaacatgtccctgttttatgcagatttaattggtctggagggagatgaaatagtggattatctgccatcttctggtgaaaagctggaggatatgactaatcagctgaaaaaacgaatgatgaagaaacgcaaagtcaaaactcttgcatttgcaattaccaatgatgtttgcatagaggtgaatacatatgcgctaatccgttcaactactccaggggcaattacatggcttgattctatcagcaacctgccattgaaggctgaaaggtctttcatatgcaatgacactggggcccttattcaggatccacaaaagcgcttccaggtgtacaatgacaaaattgttaaattctctactcgtgaattgtctgatgtgaagagggtttcaagtcatcatctacgccttttaggattcaagccactggactaccttaaagattatcacaacttaagaccgtcaacatttatttaccccagtgatgagcaaatatttggaagcactcgtgttttcgttgctttacatagctcaatgcggcgtcttggaaggtttgcacttgcattttacgggaatccaactcgcccacaacttgtagcccttattgcacaagaagaggttacttctgctggtggtcaaattgaaccacctggaatacacatgatctatcttccatactcggatgatgttagatatcctgaggaggttcatctgacttctgatgatgcacctcgtgccacagatgaacaaattaagaaagcttcaaatctattgagacgtattgatttgaagaacttctcagtatgccaattttctaacccagcattgcaaagacactatgggatcttggaggccttagctttaggtgaagatgagatgccagatgtcaaggatgaaacccttcctgatgaagagggcttggctaggccagtagtagttaaagctgtcgaggaatttaaggcttcagtctatggtgaaaattatgatcaagaggaagccgaggcagcagcagcgaaggctggggcttcaaagaagaggaaagcacttactgatgcagctgcagagaaaagtgcagcacataattgggcagaacttgcggatactggaaagctgaaggacatgacggtggtggacttgaaatcttacctgagtgcacatggcctcccagtttctggaaagaaagaggcactcgtcagcagaatcttgactcatctaggcaagtga</cdnaseq>|
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| − | AA = <aaseq>MDLDPEGLFRDDSDEDDDNVQEREANKEMVVYLIDASPKMFTPA TKADEKEETHFHTIVNCITHALKTQIIGRSYDEVAICFFNTKEKKNLQELAGVYVYNV TEREPLDRPDARLIKEFSCIEDSFMSNIGSRYGITSGSRENTLYNALWVAQALLRKGS VKTVSKRIVIFTNEDDPFGGLTGAVKTDMIRTTIQRARDAQDLGLSIELLPLSRPDEE FNMSLFYADLIGLEGDEIVDYLPSSGEKLEDMTNQLKKRMMKKRKVKTLAFAITNDVC IEVNTYALIRSTTPGAITWLDSISNLPLKAERSFICNDTGALIQDPQKRFQVYNDKIV KFSTRELSDVKRVSSHHLRLLGFKPLDYLKDYHNLRPSTFIYPSDEQIFGSTRVFVAL HSSMRRLGRFALAFYGNPTRPQLVALIAQEEVTSAGGQIEPPGIHMIYLPYSDDVRYP EEVHLTSDDAPRATDEQIKKASNLLRRIDLKNFSVCQFSNPALQRHYGILEALALGED EMPDVKDETLPDEEGLARPVVVKAVEEFKASVYGENYDQEEAEAAAAKAGASKKRKAL TDAAAEKSAAHNWAELADTGKLKDMTVVDLKSYLSAHGLPVSGKKEALVSRILTHLGK </aaseq>|
| |
| − | DNA = <dnaseqindica>59..121#219..293#506..622#1125..1239#1920..2025#2276..2393#2497..2580#2651..2709#3289..3422#3524..3567#3692..3768#4007..4154#4747..4808#8293..8353#8804..8896#8964..9081#9595..9697#9934..10117#10566..10679#ctagttggcttccagaagcttctagaaggtgcccgaggcgtcgtctcggtcgagcgccatggatctggaccccgagggcctcttccgcgacgacagcgacgaggatgacgacaacgtccaggtcgcgttccaccctgttcgagcttccctatcccccattttttctgtggctcgaatcctgtgaattgatgagcggtttggtttcttggagggaacaggagagggaggccaacaaggagatggtcgtctacctcatcgacgcctcgcccaagatgttcacccctgcgaccaaggtgaaattccagcagcttcagcgcctaatttgataaatctctctgccctgtgcgagctcaagtgttgcaattagcgatggatattgggaatgggatgatacatttaccgattattttatctgtgatgtttggtctggattggattgtctatgttcaatcaagttcttttgctaggtagtagttaagcatgttttttctgccatttattgcaggcagatgaaaaggaggagacacattttcatacgatagtgaactgcatcacacatgcgctgaagacgcagattatcggtagatcctatgatgaagtcgctatatgtttctttaacacggtaagactaattaaagaactatgtgtcatcttatatattgctatgactctgcttctattagtcagctagttaatttctttgctgtttaaatctatgatttctacaagtatttaacatccacagtgttgtaagtctacaccacactgttgcttgttagttttaattaattatattttctaagcttgacagatgaacatacttaaaatgtgaaaaaagaatcagaattgccaagtggtaaaaggaagaaaaaaaaagacaagttgctatattttggtaacagtaactcttaattggttgaaaagctgatctgaattttgttactttgcaccatggagattataaatataaatatatgattctcagataattggtaaaataatctatgatattcttatcccactcactatccttagatcattaacaatgtaggatctgtatatcgttatccttatgtcattacaagatatgcttgtttgatctggtttttacataactattgcagaaagaaaagaagaatttacaggaattggctggtgtttatgtttataatgttacagagagagaaccacttgataggcctgatgcaagattgattaaggaattttcttgtatagaaggtaatgtaattacataaattgttcttttctcaatacatgaatgtggtgatgtggtcaaggtttgtgggatatgcatgctttacttctttcatgtactaggtatggttcatagatcatcattgaattgtccaactgaacgcttgcctttcattacttgtatggaatattataggattgacatgtttgttttcttttagcaaaatattctgagaaattgtgaaatttgtgattatgcaatctttcctatcatctatctgtagaatttgtttgggttttcattttcttttgccacatcatcaccattcctattccacctgcattttctagcttacaatttgtgctgccttatatgttctatcttcttctcaaaacttatttaacagactataatgcctagtgttttagaaagtcgaacacatgatctgttatctgtgtcttgagttgcttctctgttcccattaggaacttaaggtttgataatatcatatttcttctgtaaaattgactccaagatctcattagaagcagtacatcactatttcgtattgatgttttatattatatttattttgtctgaaagtccaggtagattgaattggactgctatacttattgtgtagcaaaattgagcatccttttttgcatgacatgattctaaagcttattttgatttatggtagattcttttatgagtaatattggaagtcggtacggaataacttctggatctcgagagaataccttgtacaatgctctttgggttgcacaggcattgctgcgtaaagggtaacacaccactttccctccttcagctctaaaaagcagcatagctttaataacaaattctattagagctttaacatattctctatatacctcaacctgtttttcaggtgcactcaacaaatttaaaattttcgcatattgcgcaaaaatgatgcattttgcaccatttgcattatactgaatgttgatgaggatatttaaatactttaagtgaatgaacattctgctggtggttttataaattcttcagatctgtgaagactgtgagtaagcggattgttatattcaccaacgaagatgatccttttggtggtcttacaggagcagtaaagactgatatgataaggacaacaatccaacgtgcaagagtatgcctatgacagatatatgttcaatttcgtgctgaatcacaacaacataccatgttcttagtggcctttgtatcattaattgtctattgtcttcctacaggatgcacaagatcttggcctgtccattgaacttcttcctttgagtaggcccgatgaggagttcaacatgtccctgttttatgcagtaaatctcttttatcacatattgcgcaacccttttaagttccaacggctaaacaacacctatttcccaggatttaattggtctggagggagatgaaatagtggattatctgccatcttctggtgaaaagtattgctccctaagcatcgatttcacttgttgattgttttctgattagtgattagttgatagttgcagatttactatataccatcttttgcttgcattaccaaagtacggaacaaaagatccatcattgagtggagataacctgtgctacagaattagacgtagcaatgctgtcctctatttttctgtagtaggtggcagttctgcttggagttccctgtagtatattgttaaaatcttcaaagttgaatagcttcctgtctgtgttccagccttttgggcatcgtgtatgggatttaggtgaagtagcctctgggtgtttctcatatgaactaatgttgcactaaacttgaacctctgtatggttgctaattaatagtaatgaccgacttacactatattaagaaacctcagtaatgtctactcttggccatcaatgtcttagtcttagtcatctattaatatgcacaagctactctgttggtccctagtaattttagaattctattgtttgaacggcacagattagcttagacctagttattctcattgtcttatccagtattgtcttctttgaaggctggaggatatgactaatcagctgaaaaaacgaatgatgaagaaacgcaaagtcaaaactcttgcatttgcaattaccaatgatgtttgcatagaggtgaatacatatgcgctaatccgttcaactactccaggtatgctctaacaactggcgatatttacttctttatctctttgcataatgttgctgtgagaatgtatgtataggcttgttactgtgacatcctttttgtaggggcaattacatggcttgattctatcagcaacctgccattgaaggtgattcatgcttcatgacaaagagatcaattttgtgttactttttttttttggggggggggggagattcggagttataaaatatcaagttttatgcggtactttaacaagaatgtatgtgtaggctgaaaggtctttcatatgcaatgacactggggcccttattcaggatccacaaaagcgcttccaggtgtacaatgagtaagtacacacatgagactggtgaaccaaagcggtgttatttttgtataattttctgggttgggttctgtgatctgcttcttgattgcttcatcaagcgcagaagtctacagttatgagtcatggcacgatcattgtctcgtcattccgtcatgttgttccttttccgtttcagtttgatgcttatatttgtaatccaaaactactttatcatatattcatgcacttttttgcacagcaaaattgttaaattctctactcgtgaattgtctgatgtgaagagggtttcaagtcatcatctacgccttttaggattcaagccactggactaccttaaagattatcacaacttaagaccgtcaacatttatttaccccagtgatgaggtaataacattacttcatgtacttcttaacttcaatcttgaggccctcttggcacagctccggatccaagatttcttggagctgggtattccgagctccacaaatccatggatctggatctgtgattacgttgataaacatttggataaatcatcttgttcccatttaaaattttaaatcactataatttaatacacaaacttcaaatctaccgtttgagttacagtttgaagttatactagtacaattatctccttcatcttaattttttttgtcaaacacgcaggagagctgcgtagtcttgacaatattttgttatcttgttcgtttgttccctagattattgtacttctctagcttgaagcaataatataatagttgaaaaccttaatcattttatttgatgatattatttttcataataaaagatctatttgtgttcgatacacatccctgctgcatgctacttccaaactaaactaaatctgtctgaacatatttaggattgtattgtggtgtatgcttatttctttctcagtctttacttaaatctagggtgcatgttaggtttacctccttttgtttgatgcagcaaatatttggaagcactcgtgttttcgttgcttt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tatagagtcaagcatgttcatgttatttcagacactgaagatgaaagtgcagtctactacatattcaattcagttttacttttttgcataacaacaacgtacaacagtcacctcttgcttatgtgggttgtttcctaccactcttatctcaggccagtagtagttaaagctgtcgaggaatttaaggcttcagtctatggtgaaaattatgatcaagaggaagccgaggcagcagcagcgaaggctggggcttcaaagaagaggaaagcacttactgatgcagctgcagagaaaagtgcagcacataattgggcagaacttgcggatactggaaaggtaagcatgcaggtgctcttaccgatgggacaacaaagtgttctctaggcactgaattttactatgaaatatcttcttaatgctccaattaatctgataagaaattgtcttccagtagtttacccctctatggttctatccaccagtaattcaaaatgctagcttgcagtttgatatgccaatgtattacggaccttgcttatgtatgcaccacagcccaaaaagttttgaggcacataaataaaatgttgaaggctgtaatctcaagggaacaatacagccaggagctctatgctagtaacaattagcaactcatacttgaaacatcgatctttgcctgctttagaatttctgcctagtgatctgtcctgttcagctgttctgctctggaaatccaaatcaaccgtaaccctaatcgtttcgtaatttctgaattcgtaatttgcagctgaaggacatgacggtggtggacttgaaatcttacctgagtgcacatggcctcccagtttctggaaagaaagaggcactcgtcagcagaatcttgactcatctaggcaagtgaaatggtccacttcgacggcctactcagttttagctaactctgtaagctatctaaatttctctgaacatcttgaagtgcctatcaaaaaccctctccctgcttaggctgtgccaaattttgtagcaatatgacaacagctgaccccagttcatttggtatcatgtgcttttgtgacatgtaccactgggatttctcttaaatgtcactccagtctgcagagatcagatcattgttggtagaggaaagtgatccattagagaaagcaacaccaaacaagattattaagacattttttaagtgaagcagttgcaacc</dnaseqindica>|
| |
| − | Link = [http://www.ncbi.nlm.nih.gov/nuccore/NM_001065596.1 RefSeq:Os07g0184900]|
| |
| − | }}
| |
| − | [[Category:Genes]] | |
| − | [[Category:Japonica mRNA]]
| |
| − | [[Category:Oryza Sativa Japonica Group]] | |
| − | [[Category:Japonica Genes]] | |
| − | [[Category:Japonica Chromosome 7]]
| |
| − | [[Category:Chromosome 7]]
| |
