Difference between revisions of "Os12g0572800"
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===Function=== | ===Function=== | ||
| − | + | * In other eukaryotes, RNA-recognition-motif (RRM) proteins are known to play essential roles in germ-cell development and meiosis progression. Rice '''''MEL2''''' gene encodes MEL2 protein which shows partial similarity with human proline-rich RRM protein, deleted in Azoospermia-Associated Protein1 (DAZAP1), though MEL2 also possesses ankyrin repeats and a RING finger motif. | |
| + | * '''''MEL2''''' is required for regulating the premeiotic G1/S-phase transition of male and female germ cells and also establishing synchrony of male meiosis. | ||
===Mutation=== | ===Mutation=== | ||
| − | + | * Expression analyses of several cell-cycle markers revealed that, in '''''mel2''''' mutant anthers, most germ cells failed to enter premeiotic S-phase and meiosis, and a part escaped from the defect and underwent meiosis with a significant delay or continued mitotic cycles. | |
| − | + | ===Sublocalization=== | |
| − | === | + | * Immunofluorescent detection revealed that T7 peptide-tagged MEL2 localized at cytoplasmic perinuclear region of germ cells during premeiotic interphase in transgenic rice plants. |
| − | |||
| − | |||
===Evolution=== | ===Evolution=== | ||
Latest revision as of 15:33, 12 December 2016
The rice gene Os12g0572800 was reported as MEL2 in 2011[1] by researchers from Japan.
Contents
Annotated Information
Gene Symbol
- Os12g0572800 <=> MEL2, OSMEL2
Function
- In other eukaryotes, RNA-recognition-motif (RRM) proteins are known to play essential roles in germ-cell development and meiosis progression. Rice MEL2 gene encodes MEL2 protein which shows partial similarity with human proline-rich RRM protein, deleted in Azoospermia-Associated Protein1 (DAZAP1), though MEL2 also possesses ankyrin repeats and a RING finger motif.
- MEL2 is required for regulating the premeiotic G1/S-phase transition of male and female germ cells and also establishing synchrony of male meiosis.
Mutation
- Expression analyses of several cell-cycle markers revealed that, in mel2 mutant anthers, most germ cells failed to enter premeiotic S-phase and meiosis, and a part escaped from the defect and underwent meiosis with a significant delay or continued mitotic cycles.
Sublocalization
- Immunofluorescent detection revealed that T7 peptide-tagged MEL2 localized at cytoplasmic perinuclear region of germ cells during premeiotic interphase in transgenic rice plants.
Evolution
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Labs working on this gene
- Experimental Farm, National Institute of Genetics, Mishima, Shizuoka, Japan,
- Department of Life Science, Graduate University for Advanced Studies (SOKENDAI), Mishima, Shizuoka, Japan, 3 Laboratory for DNA Data Analysis, National Institute of Genetics, Mishima, Shizuoka, Japan,
- Division of Genome and Biodiversity Research, National Institute of Agrobiological Sciences, Tsukuba, Ibaraki, Japan,
- Plant Genetics Laboratory, National Institute of Genetics, Mishima, Shizuoka, Japan
References
- ↑ Nonomura K, Eiguchi M, Nakano M, Takashima K, Komeda N, Fukuchi S, Miyazaki S, Miyao A, Hirochika H, Kurata N. A novel RNA-recognition-motif protein is required for premeiotic G1/S-phase transition in rice (Oryza sativa L.). PLoS Genet. 2011 Jan 6;7(1):e1001265. doi: 10.1371/journal.pgen.1001265. PubMed PMID: 21253568; PubMed Central PMCID: PMC3017114.
