Difference between revisions of "Os12g0622500"
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*'''Spo11''' is essential for initiating meiotic recombination and this function appears conserved among other eukaryotes. | *'''Spo11''' is essential for initiating meiotic recombination and this function appears conserved among other eukaryotes. | ||
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*'''OsSpo11-4''' exhibited double-strand DNA cleavage activity and its enzymatic activity appears dependent on Mg2+ and independent of OsTopVIB, despite its interaction with OsTopVIB. We further analyzed the biological function of OsSpo11-4 by RNA interference and found that down-regulated expression of OsSpo11-4 led to defects in male meiosis, indicating '''OsSpo11-4''' is required for meiosis. | *'''OsSpo11-4''' exhibited double-strand DNA cleavage activity and its enzymatic activity appears dependent on Mg2+ and independent of OsTopVIB, despite its interaction with OsTopVIB. We further analyzed the biological function of OsSpo11-4 by RNA interference and found that down-regulated expression of OsSpo11-4 led to defects in male meiosis, indicating '''OsSpo11-4''' is required for meiosis. | ||
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Revision as of 11:28, 13 December 2016
The rice Os12g0622500 was reported as OsSpo11-4 in 2011 [1] by researchers from the China.
Contents
Annotated Information
Gene Symbol
- Os12g0622500 <=> OsSpo11-4
Function
- Spo11 is essential for initiating meiotic recombination and this function appears conserved among other eukaryotes.
Mutant
- OsSpo11-4 exhibited double-strand DNA cleavage activity and its enzymatic activity appears dependent on Mg2+ and independent of OsTopVIB, despite its interaction with OsTopVIB. We further analyzed the biological function of OsSpo11-4 by RNA interference and found that down-regulated expression of OsSpo11-4 led to defects in male meiosis, indicating OsSpo11-4 is required for meiosis.
Labs working on this gene
- Chinese Ministry of Science and Technology
- Natural Science Fundation of China
References
- ↑ OsSpo11-4, a Rice Homologue of the Archaeal TopVIA Protein, Mediates Double-Strand DNA Cleavage and Interacts with OsTopVIB
