Difference between revisions of "Os02g0728001"

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The Basic Leucine Zipper Domain (bZIP domain) is found in many DNA binding eukaryotic proteins. One part of the domain contains a region that mediates sequence specific DNA binding properties and the leucine zipper that is required to hold together (dimerize) two DNA binding regions. The DNA binding region comprises a number of basic amino acids such as arginine and lysine. Proteins containing this domain are transcription factors.[1][2]
 
bZIP transcription factor
 
[[File:001.jpg]]
 
  
CREB.png
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The rice '''''Os02g0728001''''' was reported as '''''OsbZIP022''''' in 2008 <ref name="ref1" /> by researchers from India.  
CREB (top) is a transcription factor capable of binding DNA via the bZIP domain (bottom) and regulating gene expression.
 
bZIP transcription factors are found in all organisms. A recent evolutionary study revealed that 4 bZIP genes were encoded by the genome of the most recent common ancestor of all plants.[3] Interactions between bZIP transcription factors play important roles in cancer development[4] in epithelial tissues, steroid hormone synthesis by cells of endocrine tissues,[5] factors affecting reproductive functions,[6] and several other phenomena that affect human health.
 
  
1.Jump up ^ Ellenberger T (1994). "Getting a grip in DNA recognition: structures of the basic region leucine zipper, and the basic region helix-loop-helix DNA-binding domains.". Curr. Opin. Struct. Biol. 4 (1): 12–21. doi:10.1016/S0959-440X(94)90054-X.
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==Annotated Information==
2.Jump up ^ Hurst HC (1995). "Transcription factors 1: bZIP proteins". Protein Profile 2 (2): 101–68. PMID 7780801.
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===Gene Symbol===
3.Jump up ^ Corrêa LGG, Riaño-Pachón DM, Schrago CG, dos Santos RV, Mueller-Roeber B, Vincentz M. (2008). "The Role of bZIP Transcription Factors in Green Plant Evolution: Adaptive Features Emerging from Four Founder Genes". In Shiu, Shin-Han. PLoS ONE 3 (8): e2944. doi:10.1371/journal.pone.0002944. PMC 2492810. PMID 18698409.
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*'''''Os02g0728001''''' '''<=>''' '''''OsbZIP022,OsbZIP, bZIP022'''''
4.Jump up ^ Vlahopoulos SA, Logotheti S, Mikas D, Giarika A, Gorgoulis V, Zoumpourlis V (April 2008). "The role of ATF-2 in oncogenesis". BioEssays 30 (4): 314–27. doi:10.1002/bies.20734. PMID 18348191.
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===Function===
5.Jump up ^ Manna PR, Dyson MT, Eubank DW, Clark BJ, Lalli E, Sassone-Corsi P, Zeleznik AJ, Stocco DM (January 2002). "Regulation of steroidogenesis and the steroidogenic acute regulatory protein by a member of the cAMP response-element binding protein family". Mol. Endocrinol. 16 (1): 184–99. doi:10.1210/me.16.1.184. PMID 11773448.
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* The basic leucine (Leu) zipper (bZIP) proteins compose a family of transcriptional regulators present exclusively in eukaryotes.
6.Jump up ^ Hoare S, Copland JA, Wood TG, Jeng YJ, Izban MG, Soloff MS (May 1999). "Identification of a GABP alpha/beta binding site involved in the induction of oxytocin receptor gene expression in human breast cells, potentiation by c-Fos/c-Jun". Endocrinology 140 (5): 2268–79. doi:10.1210/en.140.5.2268. PMID 10218980.
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* The '''''OsbZIP''''' proteins characteristically harbor a bZIP domain composed of two structural features: a DNA-binding basic region and the Leu zipper dimerization region.  
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* bZIP proteins have been shown to regulate diverse plant-specific phenomena, including seed maturation and germination, floral induction and development, and photomorphogenesis, and are also involved in stress and hormone signaling.
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===Expression===
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* The researchers from India find specific or coexpression patterns of rice bZIP transcription factors starting from floral transition to various stages of panicle and seed development.
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* bZIP transcription factor-encoding genes in rice also displayed differential expression patterns in rice seedlings in response to abiotic stress and light irradiation.
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===Evolution===
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* The phylogenetic relationship among rice bZIP domains as well as with bZIP domains from other plant bZIP factors suggests that homologous bZIP domains exist in plants.  
 +
* Similar intron/exon structural patterns were observed in the basic and hinge regions of their bZIP domains.  
 +
* Detailed sequence analysis has been done to identify additional conserved motifs outside the bZIP domain and to predict their DNA-binding site specificity as well as dimerization properties, which has helped classify them into different groups and subfamilies, respectively.
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<br>
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'''''You can also add sub-section(s) at will.'''''
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==Labs working on this gene==
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* Interdisciplinary Centre for Plant Genomics and Department of Plant Molecular Biology, University of Delhi South Campus, New Delhi 110021, India
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==References==
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<references>
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* <ref name="ref1">
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Nijhawan A, Jain M, Tyagi AK, Khurana JP. Genomic survey and gene expression
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analysis of the basic leucine zipper transcription factor family in rice. Plant
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Physiol. 2008 Feb;146(2):333-50. PubMed PMID: 18065552; PubMed Central PMCID:
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PMC2245831.
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</ref>
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</references>
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==Structured Information==
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[[Category:Genes]][[Category:Oryza Sativa Japonica Group]][[Category:Japonica Chromosome 02]]

Latest revision as of 13:51, 21 February 2017

The rice Os02g0728001 was reported as OsbZIP022 in 2008 [1] by researchers from India.

Annotated Information

Gene Symbol

  • Os02g0728001 <=> OsbZIP022,OsbZIP, bZIP022

Function

  • The basic leucine (Leu) zipper (bZIP) proteins compose a family of transcriptional regulators present exclusively in eukaryotes.
  • The OsbZIP proteins characteristically harbor a bZIP domain composed of two structural features: a DNA-binding basic region and the Leu zipper dimerization region.
  • bZIP proteins have been shown to regulate diverse plant-specific phenomena, including seed maturation and germination, floral induction and development, and photomorphogenesis, and are also involved in stress and hormone signaling.

Expression

  • The researchers from India find specific or coexpression patterns of rice bZIP transcription factors starting from floral transition to various stages of panicle and seed development.
  • bZIP transcription factor-encoding genes in rice also displayed differential expression patterns in rice seedlings in response to abiotic stress and light irradiation.

Evolution

  • The phylogenetic relationship among rice bZIP domains as well as with bZIP domains from other plant bZIP factors suggests that homologous bZIP domains exist in plants.
  • Similar intron/exon structural patterns were observed in the basic and hinge regions of their bZIP domains.
  • Detailed sequence analysis has been done to identify additional conserved motifs outside the bZIP domain and to predict their DNA-binding site specificity as well as dimerization properties, which has helped classify them into different groups and subfamilies, respectively.


You can also add sub-section(s) at will.

Labs working on this gene

  • Interdisciplinary Centre for Plant Genomics and Department of Plant Molecular Biology, University of Delhi South Campus, New Delhi 110021, India

References

  1. Nijhawan A, Jain M, Tyagi AK, Khurana JP. Genomic survey and gene expression analysis of the basic leucine zipper transcription factor family in rice. Plant Physiol. 2008 Feb;146(2):333-50. PubMed PMID: 18065552; PubMed Central PMCID: PMC2245831.

Structured Information