Difference between revisions of "Os12g0622500"
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===Gene Symbol=== | ===Gene Symbol=== | ||
*'''Os12g0622500 <=> OsSpo11-4''' | *'''Os12g0622500 <=> OsSpo11-4''' | ||
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===Function=== | ===Function=== | ||
*'''Spo11''' is essential for initiating meiotic recombination and this function appears conserved among other eukaryotes. | *'''Spo11''' is essential for initiating meiotic recombination and this function appears conserved among other eukaryotes. | ||
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===Mutant=== | ===Mutant=== | ||
*'''OsSpo11-4''' exhibited double-strand DNA cleavage activity and its enzymatic activity appears dependent on Mg2+ and independent of OsTopVIB, despite its interaction with OsTopVIB. We further analyzed the biological function of OsSpo11-4 by RNA interference and found that down-regulated expression of OsSpo11-4 led to defects in male meiosis, indicating '''OsSpo11-4''' is required for meiosis. | *'''OsSpo11-4''' exhibited double-strand DNA cleavage activity and its enzymatic activity appears dependent on Mg2+ and independent of OsTopVIB, despite its interaction with OsTopVIB. We further analyzed the biological function of OsSpo11-4 by RNA interference and found that down-regulated expression of OsSpo11-4 led to defects in male meiosis, indicating '''OsSpo11-4''' is required for meiosis. | ||
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==Labs working on this gene== | ==Labs working on this gene== | ||
*Chinese Ministry of Science and Technology | *Chinese Ministry of Science and Technology | ||
| − | *Natural Science Fundation of China | + | *Natural Science Fundation of China |
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==References== | ==References== | ||
<references> | <references> | ||
Latest revision as of 01:01, 24 February 2017
The rice Os12g0622500 was reported as OsSpo11-4 in 2011 [1] by researchers from the China.
Contents
Annotated Information
Gene Symbol
- Os12g0622500 <=> OsSpo11-4
Function
- Spo11 is essential for initiating meiotic recombination and this function appears conserved among other eukaryotes.
Mutant
- OsSpo11-4 exhibited double-strand DNA cleavage activity and its enzymatic activity appears dependent on Mg2+ and independent of OsTopVIB, despite its interaction with OsTopVIB. We further analyzed the biological function of OsSpo11-4 by RNA interference and found that down-regulated expression of OsSpo11-4 led to defects in male meiosis, indicating OsSpo11-4 is required for meiosis.
Labs working on this gene
- Chinese Ministry of Science and Technology
- Natural Science Fundation of China
References
- ↑ OsSpo11-4, a Rice Homologue of the Archaeal TopVIA Protein, Mediates Double-Strand DNA Cleavage and Interacts with OsTopVIB
