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| − | Please input one-sentence summary here.
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| − | ==Annotated Information==
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| − | ===Function===
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| − | Bub1 (for budding uninhibited by benzimidazole 1), one of the main spindle checkpoint kinases, acts as a kinetochore scaffold
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| − | for assembling other checkpoint proteins. Here, we identify a plant Bub1-related kinase 1 (BRK1) in rice (Oryza sativa). The
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| − | brk1 mutants are sterile due to the precocious separation of sister chromatids at the onset of anaphase I. The centromeric
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| − | recruitment of SHUGOSHIN1 and phosphorylation of histone H2A at Thr-134 (H2A-pT134) depend on BRK1. Although the
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| − | homologs can faithfully separate from each other at the end of meiosis I, the uncorrected merotelic attachment of paired
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| − | sister kinetochores at the early stage of metaphase I in brk1 reduces the tension across homologous kinetochores, causes
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| − | the metaphase I spindle to be aberrantly shaped, and subsequently affects the synchronicity of homolog separation at the
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| − | onset of anaphase I. In addition, the phosphorylation of inner centromeric histone H3 at Ser-10 (H3-pS10) during diakinesis
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| − | depends on BRK1. Therefore, we speculate that BRK1 may be required for normal localization of Aurora kinase before the
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| − | onset of metaphase I, which is responsible for correcting the merotelic attachment.
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