Os08g0524100

This gene belongs to Histone Deacetylase Gene family, which symbol is OsSRT1.

Annotated Information

Function

OsSRT1 is a widely expressed nuclear protein with higher levels in rapidly dividing tissues. OsSRT1 RNA interference induced an increase of histone H3K9 (lysine-9 of H3) acetylation and a decrease of H3K9 dimethylation, leading to H2O2 production, DNA fragmentation, cell death, and lesions mimicking plant hypersensitive responses during incompatible interactions with pathogens, whereas overexpression of OsSRT1 enhanced tolerance to oxidative stress. Transcript microarray analysis revealed that the transcription of many transposons and retrotransposons in addition to genes related to hypersensitive response and/or programmed cell death was activated. Chromatin immunoprecipitation assays showed that OsSRT1 down-regulation induced histone H3K9 acetylation on the transposable elements and some of the hypersensitive response-related genes, suggesting that these genes may be among the primary targets of deacetylation regulated by OsSRT1.The rice SIR2-like gene is required for safeguard against genome instability and cell damage to ensure plant cell growth, but likely implicates different molecular mechanisms than yeast and animal homologs. Overexpression of OsSRT1 Enhanced Tolerance to Oxidative Stress

[1]

Expression

Please input expression information here. Baseline expression in tissue(s) was found for OS08G0524100.And no differential experiments were found for OS08G0524100.Related picture is shown as followed.

Evolution

Rice Genome Contains Two SIR2-Related Genes(figure 1A,2A,2B)

Down-Regulation of OsSRT1 by RNAi Induced Programmed Cell Death in Rice.the OsSRT1 RNAi had little effect on overall histone H3 acetylation. However, the acetylation of H3K9 was induced, whereas the dimethylation of H3K9 was reduced, in agreement with the antagonistic relationship between H3K9 acetylation and dimethylation(3A,3B,3C)

Overexpression of OsSRT1 Enhanced Tolerance to Oxidative Stress. Transcriptomic Analysis Revealed Activation of ManyTransposon and PCD-Related Genes. OsSRT1 RNAi Induced Histone H3K9 Acetylation on Transposable Elements.

Labs working on this gene

Benhamed M, Bertrand C, Servet C, Zhou DX Blander G, Guarente L Brodersen P, PetersenM, Pike HM, Olszak B, Skov S, Odum N Carrozza MJ, Utley RT, Workman JL, Coˆ te´ J Chu Z, Yuan M, Yao J, Ge X, Yuan B, Xu C, Li X, Fu B, Li Z, Bennetzen JL, Czernic P, Huang HC, Marco Y DaiM, Hu Y, Zhao Y, Liu H, Zhou D-X Donahue JL, Okpodu CM, Cramer CL, Grabau EA, Alscher RG

References

Down-Regulation of a SILENT INFORMATION REGULATOR2-Related Histone Deacetylase Gene, OsSRT1,Induces DNA Fragmentation and Cell Death in RiceRice1.

Structured Information

overview=

Gene Name	Os08g0524100
Description	Similar to Type II inositol-1,4,5-trisphosphate 5-phosphatase 12 (EC 3.1.3.36) (At5PTase12) (FRAGILE FIBER3 protein)
Version	NM_001068820.1 GI:115477377 GeneID:4346083
Length	7362 bp
Definition	Oryza sativa Japonica Group Os08g0524100, complete gene.
Source	Oryza sativa Japonica Group ORGANISM Oryza sativa Japonica Group Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliophyta; Liliopsida; Poales; Poaceae; BEP Chromosome = Chromosome 8
Chromosome	{{{Chromosome}}}
Location	Chromosome 8:26150471..26157832
Sequence Coding Region	26150586..26151303,26152182..26152434,26152524..26153328,26154075..26154199,26154328..26154412 ,26154720..26154873,26154971..26155008,26155089..26155356,26155504..26155627 ,26155755..26156115,26157151..26157543
Expression	GEO Profiles:Os08g0524100
Genome Context	<gbrowseImage1> name=NC_008401:26150471..26157832 source=RiceChromosome08 preset=GeneLocation </gbrowseImage1>
Gene Structure	<gbrowseImage2> name=NC_008401:26150471..26157832 source=RiceChromosome08 preset=GeneLocation </gbrowseImage2>
Coding Sequence	<cdnaseq>atggactcggacgacgaggcggcggctgcggccatggcggcgcgggcgcgggagacgctgaggaagagcgcgtcgtcgtcgtcgtcgtcgccgtacgcgcgtagcaccgacgacggccccgtcgcctccgcctcgtgcgacgcgcgcctcgagcgctgctgccgcgaggttggcgccgcggtggcggtggtggaggagccggagcgggttgtttcggggggcggggcgttgccggagtttgttggtgagggagggggcgaggggatctaccgggtgccgctgcgcgccgcgatgcacccgggccgcccgccgccgctcgaggtgcggccccacccgctgcgggagacgcaggtggggtccttcctgcgggcgctggcgtgcgagccgcggcgccggcagctctgggcgggctccgagtccggggtccgcgtgtgggggctcgacgacgtgttcgccgccgccgggtgcggggcgcgccgcggcgacgaggagagcgcgcccttcagggagtccgtgcccgtgccgcccgtgctctgcgtcgaggcggacgcctcgaacgcgctggtgtggacgggccacaaggatgggaggatcatgtcgtggcgaatggacctcgccgccggcagcgacgacgatgacgcgccgttgttcagggaggccctgacgtggcaggcacacagccgcacgccagtgctctccatggtcatcacgtcttatggtgaaatatggtcaggatccgaagggggtgttataaaggcatggccctgggacgtcattgctaagtccctctcactaatgccagaagaaaaacatgtggctgctttacggattgaaaggtcatatattgaccttaggaacaatgcagcagctggcaacatatcttcgttccccgctgctgatgtgaaacacatgcttgctgaccattcccgggcaaaagtttggtgtttaactagcatggcatttgctgtttgggatgctcggaccagggaactgctaaaagtgtttggcatggacggccaaattgagtcagctcggttagaggcacctgtgatgccagagcaatttatagaggaagaaatcaaagcaaaacccgtgaagaaggataaaccacaaagctctttcaattttttccagaaatcaaggaatgccctgatgggagcagctggtgcagtacgcagagttgctacaaaagggacatttgttgaagataatcgccgaacagaagcagtggttcaggcaatgaatggaacggtttggtcaggttgcacagatggtttgatcattatgtgggatggaaatgggaaccgactgcaagaattccagcatcattgttcttctgttcagtgcatgaaggcacttggagaaagggtgtgggtgggctatgccagtggcattattcaagtcatggatgtggaaggtaaccttctggcagaatggactgggcatagctgtccggtcatacagatggcgattggtggttcttatgtctttactcttgctcatcatggtggaattagaggatggcctctagcttcccctggccctctggatgatattctgcgaactgaattgtcaaacagggagttgtcgtatagaaggctagtgaacattaaaatgcttgttgggacttggaatgttggccaggagaaagcatcttatgaatcactcatgtcatggttgggtcgtgcattttttgatgttgacttggtggtggttggtctacaagaggtcgagatgggtgctggtgttcttgccatggctgcagccaaagaaagtgtagggcttgagggtagtgccaatggtcagtggtggatagacaatattggcaggacccttgatgaggggatatccttccaccgagttggttcaaggcagctggctggattacttattgctgcatgggcaaggaaggaccttaagccacatgttggtgatgttgatgctgctgcagtaccatgtggctttgggcgtgctattggcaacaagggtggtgtagggttaagaattagagtctatgatcgcaggatatgttttgtgaacaatcattttgctgcacatctagaaaatgttagccgtcgtaatgctgattttgatcatatctatcgaacgatgacttttaacaaacctcatggatctgcagcttctgctacatctgttcaattgcataaaaccgtgaatgccaatggaaatcaggtcgatgaagatatacctgagatggcagaagctgatatggttgtctttcttggtgatttcaactaccgactttacggtatcacctatgatgaagcaagggacatggtctctcaaaggagctttgactggcttaaagaaagggatcaacttcaagcagaaatgagggcaggaaaggttttccaaggaatgcgtgaaggtttgatcagatttcctccgacttacaaattccaaagacacctaccaggtcttgcaggatatgactcgggtgagaagaagagaatacctgcttggtgcgacagaatactgtatcgagatagccgtgatgtattaacagcagagtgctcattagaatgccctgttgttgctaaaattacatcgtatgaagcttgcatgggtgtcacagatagtgatcataaaccagtgaggtgtgcatttagtgttgatattgcaagagtggatgagtttacaagaagacaggaatatggaaaaatactccaatctgacaaaagattacacagtttgcttcgagagtcccattttgttccagacactataatcagcacaaacaatataattttggaaaaccaagaacatgttgtcctccggataacaaatgattgtcaaagaaacaaggctgcttttgaaatcctgtgtgaaagccagtcaatcagcaagcaggatggaactaaatccgagtttcctccaagggcatcctttgggttgccgctttggcttgaggttgaaccatcagttggtctcattgaacctgggcaaacaatggaagttaccgtgcaccatgaagactattacacccaagaagtatttgtcaatggagtactgcagaactgttggtgcgaagtcaccagagataaggaggccgttcttttggtcaatgtaacaggtagcacctcaactgaaaccattacacacaggatcaatgtcaggcattgctgctcaacgatttctgcatccccgcccatcaatccaccgtctatcacaaccccatccgttgatgttctatcgggtgaagcatctacaagaagttcaaagaagaatccgttgaattatttgcaacgttctgactttaagccattcggcagctcagaggtgcatgatttgtgccccttgtga</cdnaseq>
Protein Sequence	<aaseq>MDSDDEAAAAAMAARARETLRKSASSSSSSPYARSTDDGPVASA SCDARLERCCREVGAAVAVVEEPERVVSGGGALPEFVGEGGGEGIYRVPLRAAMHPGR PPPLEVRPHPLRETQVGSFLRALACEPRRRQLWAGSESGVRVWGLDDVFAAAGCGARR GDEESAPFRESVPVPPVLCVEADASNALVWTGHKDGRIMSWRMDLAAGSDDDDAPLFR EALTWQAHSRTPVLSMVITSYGEIWSGSEGGVIKAWPWDVIAKSLSLMPEEKHVAALR IERSYIDLRNNAAAGNISSFPAADVKHMLADHSRAKVWCLTSMAFAVWDARTRELLKV FGMDGQIESARLEAPVMPEQFIEEEIKAKPVKKDKPQSSFNFFQKSRNALMGAAGAVR RVATKGTFVEDNRRTEAVVQAMNGTVWSGCTDGLIIMWDGNGNRLQEFQHHCSSVQCM KALGERVWVGYASGIIQVMDVEGNLLAEWTGHSCPVIQMAIGGSYVFTLAHHGGIRGW PLASPGPLDDILRTELSNRELSYRRLVNIKMLVGTWNVGQEKASYESLMSWLGRAFFD VDLVVVGLQEVEMGAGVLAMAAAKESVGLEGSANGQWWIDNIGRTLDEGISFHRVGSR QLAGLLIAAWARKDLKPHVGDVDAAAVPCGFGRAIGNKGGVGLRIRVYDRRICFVNNH FAAHLENVSRRNADFDHIYRTMTFNKPHGSAASATSVQLHKTVNANGNQVDEDIPEMA EADMVVFLGDFNYRLYGITYDEARDMVSQRSFDWLKERDQLQAEMRAGKVFQGMREGL IRFPPTYKFQRHLPGLAGYDSGEKKRIPAWCDRILYRDSRDVLTAECSLECPVVAKIT SYEACMGVTDSDHKPVRCAFSVDIARVDEFTRRQEYGKILQSDKRLHSLLRESHFVPD TIISTNNIILENQEHVVLRITNDCQRNKAAFEILCESQSISKQDGTKSEFPPRASFGL PLWLEVEPSVGLIEPGQTMEVTVHHEDYYTQEVFVNGVLQNCWCEVTRDKEAVLLVNV TGSTSTETITHRINVRHCCSTISASPPINPPSITTPSVDVLSGEASTRSSKKNPLNYL QRSDFKPFGSSEVHDLCPL</aaseq>
Gene Sequence	<dnaseqindica>116..833#1712..1964#2054..2858#3605..3729#3858..3942#4250..4403#4501..4538#4619..4886#5034..5157#5285..5645#6681..7073#atcgccatcgacgacgacgacgacgagctcgcctccccttcccttccctccacggcgcgccgcctccgcgacaggtcaccctcttcccttccatccaaacgagctcggatttaggatggactcggacgacgaggcggcggctgcggccatggcggcgcgggcgcgggagacgctgaggaagagcgcgtcgtcgtcgtcgtcgtcgccgtacgcgcgtagcaccgacgacggccccgtcgcctccgcctcgtgcgacgcgcgcctcgagcgctgctgccgcgaggttggcgccgcggtggcggtggtggaggagccggagcgggttgtttcggggggcggggcgttgccggagtttgttggtgagggagggggcgaggggatctaccgggtgccgctgcgcgccgcgatgcacccgggccgcccgccgccgctcgaggtgcggccccacccgctgcgggagacgcaggtggggtccttcctgcgggcgctggcgtgcgagccgcggcgccggcagctctgggcgggctccgagtccggggtccgcgtgtgggggctcgacgacgtgttcgccgccgccgggtgcggggcgcgccgcggcgacgaggagagcgcgcccttcagggagtccgtgcccgtgccgcccgtgctctgcgtcgaggcggacgcctcgaacgcgctggtgtggacgggccacaaggatgggaggatcatgtcgtggcgaatggacctcgccgccggcagcgacgacgatgacgcgccgttgttcagggaggccctgacgtggcaggcacacagccgcacgccagtgctctccatggtcatcacgtcttatggtgagaagcttgattacttactttgatcatctcaatcaattctatttttcattgagcaaattacgcaagggatggataaaaattggctccgtgcatagtgaggcaatagcattattgggtaaaagagcacgaagaatgattttagctgatgaaatgtttcattttagctgattttaagcgtctgaaaataacagggctttagcaacaactttagtctattacaaataaattaggaaaaacacttttggggggtggggtccagtaatattgacatcttgcaaatggaaaatctgaaagttgaactagtttttttttttctgttctgtatgacatgacatccatatatgggagtattagtgttagaagttttctcaaatggtaggcttccgttatcttttttagatgcgtttgcatggatgtaatcacttgggcgcgtttttctctttgcataaatgtggagaagtttgggaaggtaaaagtaacctaaaaaacatccacaaacaataggattagcctacgaaatgaacactcataccatagagaactttatcgaataatacaaataaatccttgttattcttgaaatattaagaaactgtctgttaataattgaagtcttaaagttcacttgtgttttagttgtctactatgtgaaaagcctacttggaagatgctttattgttgttccttttgaaacttaattttcagctttatttgttgcattggatcgctgtcaatggctgaatcattcattcgtagttatatgacattaaggcatctcttctgctccatacaagatttaaacttcacaatgtccactaaaagaggtagaacgttttgcaaaaatgatttatttcatttcaatatcttggaaacaggtgaaatatggtcaggatccgaagggggtgttataaaggcatggccctgggacgtcattgctaagtccctctcactaatgccagaagaaaaacatgtggctgctttacggattgaaaggtcatatattgaccttaggaacaatgcagcagctggcaacatatcttcgttccccgctgctgatgtgaaacacatgcttgctgaccattcccgggcaaaagtttggtgtttaactagcatggcatttgctgtttggtatgctttcataaataaattgcattatccttgagttcatcggcccattgaaaagttaggaactattttttctgatatttttcctgtagggatgctcggaccagggaactgctaaaagtgtttggcatggacggccaaattgagtcagctcggttagaggcacctgtgatgccagagcaatttatagaggaagaaatcaaagcaaaacccgtgaagaaggataaaccacaaagctctttcaattttttccagaaatcaaggaatgccctgatgggagcagctggtgcagtacgcagagttgctacaaaagggacatttgttgaagataatcgccgaacagaagcagtggttcaggcaatgaatggaacggtttggtcaggttgcacagatggtttgatcattatgtgggatggaaatgggaaccgactgcaagaattccagcatcattgttcttctgttcagtgcatgaaggcacttggagaaagggtgtgggtgggctatgccagtggcattattcaagtcatggatgtggaaggtaaccttctggcagaatggactgggcatagctgtccggtcatacagatggcgattggtggttcttatgtctttactcttgctcatcatggtggaattagaggatggcctctagcttcccctggccctctggatgatattctgcgaactgaattgtcaaacagggagttgtcgtatagaaggctagtgaacattaaaatgcttgttgggacttggaatgttggccaggagaaagcatcttatgaatcactcatgtcatggttgggtcgtgcattttttgatgttgacttggtggtggttggtctacaagaggtcgagatgggtgctggtgttcttgccatggctgcagccaaagaaagtgtaagatatgaaatactcaaccctacctttgatttcgttgtttcattgttttcttgctcggttcaatcaaggaaaaagaaactattattgagataggaaaataggttactagtgagcacaataagattatttctgcattacagcttaatttgtattatttctgataatatgactgtatctgcgctactgtcttttgaaaaacacaagtggtgtgcttgtctttctgataaaatggttgtactatgttacattttaatttttatccttcttatctctatctggagctcatatgattctaatttagctgcttgaaacaaatactgcatatacctaagcataagggttcattctagagctctaggtgcagattacctttttacagttttttttttgtgagaaggcacaggagaactgtgtatatttctgttagtataaaaatgatgaacactgaaactgaagttaagagttgtcttttacagttattgcagctgtatgtttgggaagtcaatgcatttgctttcatgctagtttgtttgctgtggtgttttattggtataataaagctaccactgagaactggaaggaaaatttaatttaatttcctatctggtcatcatctcccccttcttcctgtttctgtctgattttcatatctagactgcactgggctatttcctgtactggtatcatgcctgctatgtgagttttgagcattttattcaacatttcttgctttatggccttaggtagggcttgagggtagtgccaatggtcagtggtggatagacaatattggcaggacccttgatgaggggatatccttccaccgagttggttcaaggcagctggctggattacttattgctgcatggtactggtttatcttaaaaccatttcttagtgaaacatttttctgttattatataattatcattttttttgcacttttgtacttttctcatacgatatgtatggcatgtacatcatgataatttcaagggcaaggaaggaccttaagccacatgttggtgatgttgatgctgctgcagtaccatgtggctttgggcgtgctattggcaacaaggtacatgattgtcaaaatgtttattaactgtttgttcttgagcgtatcatatgtgcactataccaactgggaatttcgttcacgcaaagaacattatactgctgtgataaataatcatgggatactcaaaatatgtttttcttcacatacttcatccaactagaaacaatttgtgagcgtgcaatggttagaggtgaaagtgtgcagctgcagttttcagaggaaaattattttaatagttagcaatatattgctctattctttttcctattttgcattgaataatgatatctcattcttcttgcagggtggtgtagggttaagaattagagtctatgatcgcaggatatgttttgtgaacaatcattttgctgcacatctagaaaatgttagccgtcgtaatgctgattttgatcatatctatcgaacgatgacttttaacaaacctcatggatctgcaggtacttcattctcaactttcatcttataagtatatttaaatactagtttgttgtaaatgaattctataacatcttttttttttggtttcctctacagcttctgctacatctgttcaattgcataaaaccgtgaatgtatgtaatcgctgaactgcattgcagatttttccgtggaaataaagaatacttatttatagctattgtcataatggcaggccaatggaaatcaggtcgatgaagatatacctgagatggcagaagctgatatggttgtctttcttggtgatttcaactaccgactttacggtatcacctatgatgaagcaagggacatggtctctcaaaggagctttgactggcttaaagaaagggatcaacttcaagcagaaatgagggcaggaaaggttttccaaggaatgcgtgaaggtttgatcagatttcctccgacttacaaattccaaagacacctaccaggtcttgcaggtatggcctgtttttacttttgatgctagcggcacctccttaattaaatagttccagttctgtcacaagattcaaatgttcttttatgtgctgattaaattgacgcaactgctttggagctaatttttccacaccaaaaataattaggatatgactcgggtgagaagaagagaatacctgcttggtgcgacagaatactgtatcgagatagccgtgatgtattaacagcagagtgctcattagaatgccctgttgttgctaaaattacatcgtaagattctacaacttaccagttaccactcgttttgagaaggagaatctaagacacacatgttgttttgtcttgatcataatcactccctcatacataatttgatgttttattgctcttctggtaggtatgaagcttgcatgggtgtcacagatagtgatcataaaccagtgaggtgtgcatttagtgttgatattgcaagagtggatgagtttacaagaagacaggaatatggaaaaatactccaatctgacaaaagattacacagtttgcttcgagagtcccattttgttccagacactataatcagcacaaacaatataattttggaaaaccaagaacatgttgtcctccggataacaaatgattgtcaaagaaacaaggctgcttttgaaatcctgtgtgaaagccagtcaatcagcaagcaggatggaactaaatccgagtttcctccaagggcatcctttgggttgccgctttggcttgaggtatgcattaatatgtttatttgtttattcctgcattcatttttttcttttgtttagtcttaaaacccattgtgtttttcccttattaagaaaaaagaaaacccatagtgttacactctcagttgagtgttctatttctatctgtagtgttgaccattcttttgcttgtatatagaaagcctgttaagttcaaaaccatagaaagtctgtccattatgtattcagtttgcaagacctaaaataaaatttagctcataaatatagaagatatcttgtcattctagaatatgaattttggacaaccatggaacctatatactcccctcacataatgtaaaagagaagggatggagtattttacttctatgacatgcactttctgtatcagctgcactccaacctctttgtgagaactatatcagactttcttttaattatgagaaagcaaactgaaggaaaaaaattgcaaaagcaaatgagatgaaacacaatttcgatcaccttgtacctagacagtcatggaggtgggctcaggtttggttgcatgtattgtcttctagtggtcatttaggatactctttgtggacatatatttggtcaaaatcataccaaactttgcatgagttgatagacaacatcatatgatcatatctgtcagtgctcagttcataaatgtgtttcagccaaaaatcctaatgcctcatttgcatgaacccaaatcctggcctatccacatctatgggctaggattttagctcaaattcccaacccatcccatacacgtggatgggctgccatttaacccatccatataagcctaaactggatatggatctcagtggagttgctgactgaccagtttgtcatgacagtcaacagacaagaacagctgctaccactaaccattcataacaagccttttgacttgagtgttatactagtttattatatttttcagtgctttgcatgttccattttgcttttcacagtaccaatatttggtaatttaatcattcatcgtgctatgttttacaggttgaaccatcagttggtctcattgaacctgggcaaacaatggaagttaccgtgcaccatgaagactattacacccaagaagtatttgtcaatggagtactgcagaactgttggtgcgaagtcaccagagataaggaggccgttcttttggtcaatgtaacaggtagcacctcaactgaaaccattacacacaggatcaatgtcaggcattgctgctcaacgatttctgcatccccgcccatcaatccaccgtctatcacaaccccatccgttgatgttctatcgggtgaagcatctacaagaagttcaaagaagaatccgttgaattatttgcaacgttctgactttaagccattcggcagctcagaggtgcatgatttgtgccccttgtgaaacatgtaaaaatgagtgtgtctgtgtgtttttgtctgtttggtgtagcagttctgtataggagttgagtcttacgttacttaccaaagggagaattaaggtgtcccactgttaattctgtagatattcaccactgacttctcaccattcgttgagtaacatcagaaaggaaatgtgtgcatagttacaagatatctcatgtagtttttttttttcctcttctttttatagaggacacatggtgatacaaaatattctttacaggttgaatacaaagaaagttacttcg</dnaseqindica>
External Link(s)	NCBI Gene:Os08g0524100, RefSeq:Os08g0524100