Accession PRJCA003506
Title Single-Cell Transcriptomics reveals novel immune mechanisms of the onset and progression of IgA nephropathy
Relevance Medical
Data types Transcriptome or Gene expression
Organisms Homo sapiens
Description IgA nephropathy represents the most prevalent chronic nephrosis worldwide. However, pathogenesis about IgA deposition and end-stage renal failure is still not well defined. Using single-cell RNA-seq, we identified the mesangial membrane receptor for IgA, which collaborates with increased extracellular matrix proteins and protease inhibitor to facilitate IgA deposition. Meanwhile, cell-cell interaction analysis revealed increased communications between mesangium and other cell types, uncovering how morbidity inside glomerulus spreads to whole kidney, which results in the genetic changes of kidney resident immune cells. Prominent interaction decreasing in intercalated cells leads to the discovery of a transitional cell type, which exhibited significant EMT and fibrosis features. Our work comprehensively characterized the pathological mesangial signatures, highlighting the step-by-step pathogenic process of IgA nephropathy from mesangium to epithelium.
Sample scope Single cell
Release date 2021-01-20
Grants
Agency program Grant ID Grant title
Beijing Advanced Innovation Center for Genomics N/A
National Natural Science Foundation of China (NSFC) 81700619
National Natural Science Foundation of China (NSFC) 31625018
National Natural Science Foundation of China (NSFC) 81521002
Submitter Fuchou    Tang  (tangfuchou@pku.edu.cn)
Organization Peking University
Submission date 2020-09-21

Project Data

Resource name Description
BioSample (3620)  show -