| 项目编号 | PRJCA003506 | ||||||||||||||||||||
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| 项目标题 | Single-Cell Transcriptomics reveals novel immune mechanisms of the onset and progression of IgA nephropathy | ||||||||||||||||||||
| 涉及领域 | Medical | ||||||||||||||||||||
| 数据类型 | Transcriptome or Gene expression | ||||||||||||||||||||
| 物种名称 | Homo sapiens | ||||||||||||||||||||
| 描述信息 | IgA nephropathy represents the most prevalent chronic nephrosis worldwide. However, pathogenesis about IgA deposition and end-stage renal failure is still not well defined. Using single-cell RNA-seq, we identified the mesangial membrane receptor for IgA, which collaborates with increased extracellular matrix proteins and protease inhibitor to facilitate IgA deposition. Meanwhile, cell-cell interaction analysis revealed increased communications between mesangium and other cell types, uncovering how morbidity inside glomerulus spreads to whole kidney, which results in the genetic changes of kidney resident immune cells. Prominent interaction decreasing in intercalated cells leads to the discovery of a transitional cell type, which exhibited significant EMT and fibrosis features. Our work comprehensively characterized the pathological mesangial signatures, highlighting the step-by-step pathogenic process of IgA nephropathy from mesangium to epithelium. | ||||||||||||||||||||
| 样品范围 | Single cell | ||||||||||||||||||||
| 发布日期 | 2021-01-20 | ||||||||||||||||||||
| 出版信息 |
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| 项目资金来源 |
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| 提交者 | Fuchou Tang (tangfuchou@pku.edu.cn) | ||||||||||||||||||||
| 提交单位 | Peking University | ||||||||||||||||||||
| 提交日期 | 2020-09-21 |
| 资源名称 | 描述 |
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| BioSample (3620) show | - |